PMID- 29880255
OWN - NLM
STAT- MEDLINE
DCOM- 20190924
LR  - 20190925
IS  - 1872-7506 (Electronic)
IS  - 0925-4927 (Linking)
VI  - 278
DP  - 2018 Aug 30
TI  - Trait and state anxiety is marked by increased working memory-related parietal 
      BOLD signal.
PG  - 92-97
LID - S0925-4927(17)30283-4 [pii]
LID - 10.1016/j.pscychresns.2018.05.009 [doi]
AB  - Anxiety is associated with compromised cognitive control functions, such as 
      working memory. State and trait anxiety within the non-clinical population can be 
      utilised to investigate potential neural markers for anxiety, which may help to 
      elucidate potential prevention and intervention methods. Thirty-two healthy 
      adults (20 female, 12 male), aged between 30 and 65 years, performed a 2-back 
      task whilst fMRI BOLD signal was acquired using a 3T scanner. Mean BOLD signal 
      was obtained in cognitive control network regions of interest of: left and right 
      dorsolateral prefrontal cortex (DLPFC) and posterior parietal lobe (PPL), and 
      medial prefrontal cortex (MPFC). State and trait anxiety levels were recorded. 
      Higher overall anxiety was moderately associated with more left and right PPL 
      BOLD signal; there was a weak relationship between anxiety and left DLPFC BOLD 
      signal. MPFC BOLD signal and trait anxiety were moderately associated with 
      overall 2-back task performance. These findings suggest that non-clinical anxiety 
      affects the recruitment of cortical resources during working memory, but that 
      anxiety does not impair performance during a 2-back task.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Ford, Talitha C
AU  - Ford TC
AD  - Centre for Human Psychopharmacology, Swinburne University of Technology, 
      Melbourne, Australia. Electronic address: tcford@swin.edu.au.
FAU - Simpson, Tamara
AU  - Simpson T
AD  - Centre for Human Psychopharmacology, Swinburne University of Technology, 
      Melbourne, Australia.
FAU - McPhee, Grace
AU  - McPhee G
AD  - Centre for Human Psychopharmacology, Swinburne University of Technology, 
      Melbourne, Australia.
FAU - Stough, Con
AU  - Stough C
AD  - Centre for Human Psychopharmacology, Swinburne University of Technology, 
      Melbourne, Australia.
FAU - Downey, Luke A
AU  - Downey LA
AD  - Centre for Human Psychopharmacology, Swinburne University of Technology, 
      Melbourne, Australia; Institute for Breathing and Sleep, Austin Hospital, 
      Melbourne, Australia. Electronic address: ldowney@swin.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180516
PL  - Netherlands
TA  - Psychiatry Res Neuroimaging
JT  - Psychiatry research. Neuroimaging
JID - 101723001
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anxiety/*diagnostic imaging/*physiopathology/psychology
MH  - Cognition
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Middle Aged
MH  - Parietal Lobe/diagnostic imaging/metabolism/*physiology
MH  - Prefrontal Cortex/diagnostic imaging/metabolism/*physiology
OTO - NOTNLM
OT  - 2-back
OT  - Dorsolateral prefrontal cortex
OT  - Fmri
OT  - Medial prefrontal cortex
OT  - N-back
OT  - Posterior parietal
EDAT- 2018/06/09 06:00
MHDA- 2019/09/26 06:00
CRDT- 2018/06/09 06:00
PHST- 2017/10/10 00:00 [received]
PHST- 2018/05/13 00:00 [revised]
PHST- 2018/05/15 00:00 [accepted]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2019/09/26 06:00 [medline]
PHST- 2018/06/09 06:00 [entrez]
AID - S0925-4927(17)30283-4 [pii]
AID - 10.1016/j.pscychresns.2018.05.009 [doi]
PST - ppublish
SO  - Psychiatry Res Neuroimaging. 2018 Aug 30;278:92-97. doi: 
      10.1016/j.pscychresns.2018.05.009. Epub 2018 May 16.