PMID- 29880374
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20181004
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 50
IP  - 5
DP  - 2018 Jun
TI  - Pancreas Transplantation at a Single Latin-American Center; Overall Results with 
      Type 1 and Type 2 Diabetes Mellitus.
PG  - 1475-1481
LID - S0041-1345(18)30272-0 [pii]
LID - 10.1016/j.transproceed.2018.03.022 [doi]
AB  - BACKGROUND: Simultaneous pancreas-kidney transplantation (SPK) has become the 
      treatment of choice for type 1 diabetes mellitus (T1DM) patients with chronic 
      renal failure. Type 2 diabetes mellitus (T2DM), was once considered to be a 
      contraindication for pancreas transplantation; however, it has been accepted as a 
      new indication, under strict criteria. Although favorable results have increase 
      the indication for T2DM in developed countries, there have been no reports of 
      long-term results for this indication from Latin American centers. METHODS: From 
      April 2008 to March 2016, patients receiving SPK or pancreas transplant alone 
      (PTA) for T2DM were included and compared with T1DM recipients. Variables were 
      compared between groups with the use of chi(2) and t tests; Kaplan-Meier with log 
      rank was used for patient and graft survivals; P < .05 was considered to be 
      significant. RESULTS: A total of 45 SPK and 1 PTA were performed, 35 (76.1%) for 
      T1DM and 11 (24.5%) for T2DM. Mean pre-transplantation C-peptide was 
      significantly higher in the T2DM group (P = .01); HbA(1c) was higher in the T1DM 
      group (P = .03). No differences were found in weight, body mass index, and 
      pre-transplantation glycemia. Patient survivals for T1DM recipients were 88.2% 
      and 84.8% at 1 and 5 years, respetively, versus 100% and 74.1% for T2DM 
      recipients (P = .87). CONCLUSIONS: Our initial prospective experience in a single 
      Latin American center showed that medium- and long-term outcomes for T1DM and 
      T2DM individuals receiving pancreas transplants are similar, under strict 
      selection criteria.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Gondolesi, G E
AU  - Gondolesi GE
AD  - Unidad de Trasplante Reno-Pancreatico, Hospital Universitario-Fundacion Favaloro, 
      Buenos Aires, Argentina. Electronic address: ggondolesi@ffavaloro.org.
FAU - Aguirre, N F
AU  - Aguirre NF
AD  - Unidad de Trasplante Reno-Pancreatico, Hospital Universitario-Fundacion Favaloro, 
      Buenos Aires, Argentina.
FAU - Ramisch, D A
AU  - Ramisch DA
AD  - Unidad de Trasplante Reno-Pancreatico, Hospital Universitario-Fundacion Favaloro, 
      Buenos Aires, Argentina.
FAU - Mos, F A
AU  - Mos FA
AD  - Unidad de Trasplante Reno-Pancreatico, Hospital Universitario-Fundacion Favaloro, 
      Buenos Aires, Argentina.
FAU - Pedraza, N F
AU  - Pedraza NF
AD  - Unidad de Trasplante Reno-Pancreatico, Hospital Universitario-Fundacion Favaloro, 
      Buenos Aires, Argentina.
FAU - Fortunato, M R
AU  - Fortunato MR
AD  - Unidad Renal, Hospital Universitario-Fundacion Favaloro, Buenos Aires, Argentina.
FAU - Gutierrez, L M
AU  - Gutierrez LM
AD  - Unidad Renal, Hospital Universitario-Fundacion Favaloro, Buenos Aires, Argentina.
FAU - Fraguas, H
AU  - Fraguas H
AD  - Unidad de Cirugia Cardiovascular y Trasplante, Hospital Universitario-Fundacion 
      Favaloro, Buenos Aires, Argentina.
FAU - Marrugat, R
AU  - Marrugat R
AD  - Unidad Renal, Hospital Universitario-Fundacion Favaloro, Buenos Aires, Argentina.
FAU - Rabin, G E
AU  - Rabin GE
AD  - Unidad Renal, Hospital Universitario-Fundacion Favaloro, Buenos Aires, Argentina.
FAU - Musso, C
AU  - Musso C
AD  - Unidad Metabolica, Hospital Universitario-Fundacion Favaloro, Buenos Aires, 
      Argentina.
FAU - Farinelli, P A
AU  - Farinelli PA
AD  - Unidad de Cirugia Cardiovascular y Trasplante, Hospital Universitario-Fundacion 
      Favaloro, Buenos Aires, Argentina.
FAU - Barros Schelotto, P H L
AU  - Barros Schelotto PHL
AD  - Instituto de Trasplante Multiorganico, Hospital Universitario-Fundacion Favaloro, 
      Buenos Aires, Argentina.
FAU - Raffaele, P M
AU  - Raffaele PM
AD  - Unidad Renal, Hospital Universitario-Fundacion Favaloro, Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
DEP - 20180312
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 1/*surgery
MH  - Diabetes Mellitus, Type 2/*surgery
MH  - Female
MH  - Graft Survival
MH  - Humans
MH  - Kidney Failure, Chronic/surgery
MH  - Kidney Transplantation/adverse effects/methods
MH  - Latin America
MH  - Male
MH  - Middle Aged
MH  - Pancreas Transplantation/adverse effects/*methods
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2018/06/09 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/06/09 06:00
PHST- 2018/02/07 00:00 [received]
PHST- 2018/03/06 00:00 [accepted]
PHST- 2018/06/09 06:00 [entrez]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
AID - S0041-1345(18)30272-0 [pii]
AID - 10.1016/j.transproceed.2018.03.022 [doi]
PST - ppublish
SO  - Transplant Proc. 2018 Jun;50(5):1475-1481. doi: 
      10.1016/j.transproceed.2018.03.022. Epub 2018 Mar 12.