PMID- 29881418
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1735-0328 (Print)
IS  - 1726-6890 (Electronic)
IS  - 1726-6882 (Linking)
VI  - 17
IP  - 2
DP  - 2018 Spring
TI  - Pre-Treatment with Erythropoietin Attenuates Bilateral Renal Ischemia-Induced 
      Cognitive Impairments.
PG  - 601-612
AB  - One of the most common causes of mortality in acute kidney injury is brain 
      dysfunction. Here we investigated the possible protective effect of 
      erythropoietin (EPO) on cognitive impairments induced by bilateral renal ischemia 
      (BRI). Eighty male Wistar rats were allocated into 8 groups: 1, 2) Sham +V 
      (Vehicle), 3, 4) Sham+EPO, 5, 6) BRI+V, 7, 8) BRI+EPO. The groups followed by the 
      reperfusion periods of 24hours (24 h) and 1week (1w). EPO or saline was 
      administrated 30 min before surgery (1000 IU/kg, i.p). The cognitive function was 
      assessed by passive avoidance learning and Morris water maze tests. Hippocampal 
      brain-derived neurotrophic factor (BDNF) protein expression was assessed by 
      western blotting. BUN (blood urea nitrogen) and creatinine (Cr) concentrations 
      were significantly increased in BRI+V group 24 h after reperfusion. BRI+V rats 
      had just an increased level of BUN but not Cr 1w after reperfusion. EPO reversed 
      passive avoidance learning impairments observed in BRI+V group 24 h after 
      reperfusion. There were no significant differences in spatial and passive 
      avoidance learning between experimental groups 1w after reperfusion and 
      histological evaluation confirmed the behavioral data. BRI significantly 
      decreased the BDNF protein expression in the hippocampus and EPO increased that 
      24 h after operation. These observations showed protective effect of EPO against 
      cognitive dysfunctions following BRI 24 h after reperfusion through increase in 
      BDNF protein expression.
FAU - Tahamtan, Mahshid
AU  - Tahamtan M
AD  - Intracellular Recording Lab, Kerman Neuroscience Research Center, 
      Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
FAU - Sheibani, Vahid
AU  - Sheibani V
AD  - Intracellular Recording Lab, Kerman Neuroscience Research Center, 
      Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
FAU - Shid Moosavi, Seyed Mostafa
AU  - Shid Moosavi SM
AD  - Physiology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Asadi-Shekaari, Majid
AU  - Asadi-Shekaari M
AD  - Intracellular Recording Lab, Kerman Neuroscience Research Center, 
      Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
FAU - Esmaeili-Mahani, Saeed
AU  - Esmaeili-Mahani S
AD  - Intracellular Recording Lab, Kerman Neuroscience Research Center, 
      Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
AD  - Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, 
      Kerman, Iran.
FAU - Aghaei, Iraj
AU  - Aghaei I
AD  - Department of Neuroscience, Neuroscience Research Center, Poursina Hospital, 
      Guilan University of Medical Sciences, Rasht, Iran..
FAU - Shabani, Mohammad
AU  - Shabani M
AD  - Intracellular Recording Lab, Kerman Neuroscience Research Center, 
      Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
AD  - Department of Physiology, School of Medicine, Jiroft University of Medical 
      Sciences, Jiroft, Kerman, Iran.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Iran J Pharm Res
JT  - Iranian journal of pharmaceutical research : IJPR
JID - 101208407
PMC - PMC5985178
OTO - NOTNLM
OT  - Acute Kidney Injury
OT  - Bilateral Renal Ischemia
OT  - Cognitive Impairments
OT  - Erythropoietin
OT  - Memory
EDAT- 2018/06/09 06:00
MHDA- 2018/06/09 06:01
PMCR- 2018/03/01
CRDT- 2018/06/09 06:00
PHST- 2018/06/09 06:00 [entrez]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2018/06/09 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - ijpr-17-601 [pii]
PST - ppublish
SO  - Iran J Pharm Res. 2018 Spring;17(2):601-612.