PMID- 29881419
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1735-0328 (Print)
IS  - 1726-6890 (Electronic)
IS  - 1726-6882 (Linking)
VI  - 17
IP  - 2
DP  - 2018 Spring
TI  - Evaluation of Anxiolytic and Antidepressant-like Activity of Aqueous Leaf Extract 
      of Nymphaea Lotus Linn. in Mice.
PG  - 613-626
AB  - The search for psychoactive plants possessing therapeutic potential in the 
      treatment of anxiety and depression has attracted growing interest. One such 
      plant, Nymphaea lotus (commonly known as water lily), is used in traditional 
      medicine for analgesic and sedative effects. The present study sought to assess 
      the anti-anxiety and antidepressant activities of crude leaf extract of N. lotus 
      and determine possible mechanisms of action. Barbiturate sleep induction, 
      rota-rod, light/dark box, elevated plus maze, forced swimming test (FST) and open 
      field test (OFT) were conducted. Male Albino Swiss mice were treated orally with 
      vehicle 10 mL/kg, imipramine 15 mg/kg (reference drug in the FST), diazepam 1 or 
      5 mg/kg (reference drug in the OFT) or N. lotus extract (CEN) 20, 60 or 180 
      mg/kg. Mice were pretreated with p-chlorophenylalanine methyl ester (PCPA) 100 
      mg/kg, alpha-methyl-p-tyrosine (AMPT) 100 mg/kg, prazosin (PRAZ) 0.5 mg/kg or 
      yohimbine (YOH) 1 mg/kg prior to oral administration of vehicle 10 mL/kg or CEN 
      20 mg/kg to determine potential mechanisms of action. Monoamine oxidase (MAO) 
      assay and quantification of brain derived neurotrophic factor (BDNF) were 
      performed. CEN potentiated sodium pentobarbital-induced hypnotic effect and 
      anxiolytic-like effect without altering immobility time in FST. Both MAO activity 
      and BDNF level remained unchanged. These results suggest anxiolytic-like effect 
      of CEN and involvement of noradrenergic mechanism due to the blockade of 
      anxiolytic-like effect by AMPT and PRAZ.
FAU - Fajemiroye, James Oluwagbamigbe
AU  - Fajemiroye JO
AD  - Department of Pharmacological Sciences, Federal University of Goias, Campus 
      Samambaia, 74001-970, Goiania, GO, Brazil.
AD  - Department of Biomolecular Sciences, Division of Pharmacognosy, School of 
      Pharmacy, University of Mississippi, 38677, USA.
FAU - Adam, Keasling
AU  - Adam K
AD  - Department of Biomolecular Sciences, Division of Pharmacognosy, School of 
      Pharmacy, University of Mississippi, 38677, USA.
FAU - Jordan K, Zjawiony
AU  - Jordan K Z
AD  - Department of Biomolecular Sciences, Division of Pharmacognosy, School of 
      Pharmacy, University of Mississippi, 38677, USA.
FAU - Alves, Costa Elson
AU  - Alves CE
AD  - Department of Pharmacological Sciences, Federal University of Goias, Campus 
      Samambaia, 74001-970, Goiania, GO, Brazil.
FAU - Aderoju, Adeleke Adesiyan
AU  - Aderoju AA
AD  - Department of Botany, Obafemi Awolowo University, PMB 1992, Ile-Ife, Osun State, 
      Nigeria.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Iran J Pharm Res
JT  - Iranian journal of pharmaceutical research : IJPR
JID - 101208407
PMC - PMC5985179
OTO - NOTNLM
OT  - Adrenergic activity
OT  - Anxiety
OT  - Depression
OT  - Mice
OT  - Nymphaea lotus
EDAT- 2018/06/09 06:00
MHDA- 2018/06/09 06:01
PMCR- 2018/03/01
CRDT- 2018/06/09 06:00
PHST- 2018/06/09 06:00 [entrez]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2018/06/09 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - ijpr-17-613 [pii]
PST - ppublish
SO  - Iran J Pharm Res. 2018 Spring;17(2):613-626.