PMID- 29881422
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1735-0328 (Print)
IS  - 1726-6890 (Electronic)
IS  - 1726-6882 (Linking)
VI  - 17
IP  - 2
DP  - 2018 Spring
TI  - Wedelolactone from Vietnamese Eclipta prostrata (L) L. Protected Zymosan-induced 
      shock in Mice.
PG  - 653-660
AB  - Wedelolactone is known to have biological activities such as anti-inflammation 
      hepatitis, anti-hepatotoxic activity, and trypsin inhibitory effect. However, up 
      to date, there has not been any deep study on the role of wedelolactone for 
      zymosan-induced signaling pathways in the process of regulating the excessive 
      inflammatory responses in host. Here, we demonstrated that wedelolactone plays an 
      essential role for regulation of zymosan-induced inflammatory responses in murine 
      bone marrow-derived macrophages (BMDMs). The zymosan-mediated secretion of tumor 
      necrosis factor-alpha (TNF)-alpha), interleukin (IL)-6), and IL12p40 but not IL-10 in 
      BMDMs was significantly inhibited by pre-treatment with wedelolactone (30 microg/mL, 
      P < 0.001). Furthermore, zymosan-induced supreoxide generation, NADPH oxidase (P 
      < 0.001), phosphorylation of p47phox in BMDMs were significantly reduced by 
      pre-treatment of wedelolactone (30 microg/mL). Collectively, these data indicated 
      that wedelolactone reduced zymosan-induced inflammatory responses. Moreover, 
      in-vivo wedelolactone (30 mg/kg) was significantly rescued from zymosan-induced 
      shock through inhibition of systemic inflammatory cytokine levels.
FAU - Cuong, Trinh Tat
AU  - Cuong TT
AD  - Key Laboratory for Enzyme and Protein Technology, Hanoi University of Science, 
      Hanoi, Vietnam.
FAU - Diem, Giang Huy
AU  - Diem GH
AD  - Key Laboratory for Enzyme and Protein Technology, Hanoi University of Science, 
      Hanoi, Vietnam.
FAU - Doan, Tran Trung
AU  - Doan TT
AD  - Key Laboratory for Enzyme and Protein Technology, Hanoi University of Science, 
      Hanoi, Vietnam.
FAU - Huy, Nguyen Quang
AU  - Huy NQ
AD  - Faculty of Biology, Hanoi University of Science, Hanoi, Vietnam.
FAU - Phuong, Nguyen
AU  - Phuong N
AD  - National centre for Technological progress, Hanoi, Vietnam.
FAU - Hung, Hoang The
AU  - Hung HT
AD  - Institute of scientific research in military logistics/military academy of 
      logistic, Hanoi, Vietnam.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Iran J Pharm Res
JT  - Iranian journal of pharmaceutical research : IJPR
JID - 101208407
PMC - PMC5985182
OTO - NOTNLM
OT  - Inflammation
OT  - Reactive oxygen species
OT  - Wedelolactone
OT  - sepsis
OT  - zymosan
EDAT- 2018/06/09 06:00
MHDA- 2018/06/09 06:01
PMCR- 2018/03/01
CRDT- 2018/06/09 06:00
PHST- 2018/06/09 06:00 [entrez]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2018/06/09 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - ijpr-17-653 [pii]
PST - ppublish
SO  - Iran J Pharm Res. 2018 Spring;17(2):653-660.