PMID- 29882884
OWN - NLM
STAT- MEDLINE
DCOM- 20181023
LR  - 20221207
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 6
DP  - 2018 May 23
TI  - The Effect of Low-Carbohydrate Diet on Glycemic Control in Patients with Type 2 
      Diabetes Mellitus.
LID - 10.3390/nu10060661 [doi]
LID - 661
AB  - OBJECTIVE: In China, a low-fat diet (LFD) is mainly recommended to help improve 
      blood glucose levels in patients with type 2 diabetes mellitus (T2DM). However, a 
      low-carbohydrate diet (LCD) has been shown to be effective in improving blood 
      glucose levels in America and England. A few studies, primarily randomized 
      controlled trials, have been reported in China as well. METHOD: Firstly, we 
      designed two 'six-point formula' methods, which met the requirements of LCD and 
      LFD, respectively. Fifty-six T2DM patients were recruited and randomly allocated 
      to the LCD group (n = 28) and the LFD group (n = 28). The LCD group received 
      education about LCD's six-point formula, while the LFD group received education 
      about LFD's six-point formula. The follow-up time was three months. The 
      indicators for glycemic control and other metabolic parameters were collected and 
      compared between the two groups. RESULTS: Forty-nine patients completed the 
      study. The proportions of calories from three macronutrients the patients 
      consumed met the requirements of LCD and LFD. Compared to the LFD group, there 
      was a greater decrease in HbA1c level in the LCD group (-0.63% vs. -0.31%, p < 
      0.05). The dosages of insulin and fasting blood glucoses (FBG) in the third month 
      were lower than those at baseline in both groups. Compared with baseline values, 
      body mass index (BMI) and total cholesterol (TC) in the LCD group were 
      significantly reduced in the third month (p < 0.05); however, there were no 
      statistically significant differences in the LFD group. CONCLUSIONS: LCD can 
      improve blood glucose more than LFD in Chinese patients with T2DM. It can also 
      regulate blood lipid, reduce BMI, and decrease insulin dose in patients with 
      T2DM. In addition, the six-point formula is feasible, easily operable, and a 
      practical educational diet for Chinese patients with T2DM.
FAU - Wang, Li-Li
AU  - Wang LL
AD  - School of Nursing, Medical College, Soochow University, Suzhou 215006, China. 
      wanglili83476@suda.edu.cn.
FAU - Wang, Qi
AU  - Wang Q
AD  - School of Nursing, Medical College, Soochow University, Suzhou 215006, China. 
      xuweipan@whu.edu.cn.
FAU - Hong, Yong
AU  - Hong Y
AD  - School of Nursing, Medical College, Soochow University, Suzhou 215006, China. 
      20175231003@stu.suda.edu.cn.
FAU - Ojo, Omorogieva
AU  - Ojo O
AUID- ORCID: 0000-0003-0071-3652
AD  - Department of Adult Nursing and Paramedic Science, University of Greenwich, 
      London SE9 2UG, UK. o.ojo@greenwich.ac.uk.
FAU - Jiang, Qing
AU  - Jiang Q
AD  - School of Nursing, Medical College, Soochow University, Suzhou 215006, China. 
      jiangqing2015@suda.edu.cn.
FAU - Hou, Yun-Ying
AU  - Hou YY
AD  - School of Nursing, Medical College, Soochow University, Suzhou 215006, China. 
      houyunying@suda.edu.cn.
FAU - Huang, Yu-Hua
AU  - Huang YH
AD  - Medical College, Soochow University, Suzhou 215006, China. 
      Huangyuhua@suda.edu.cn.
FAU - Wang, Xiao-Hua
AU  - Wang XH
AD  - School of Nursing, Medical College, Soochow University, Suzhou 215006, China. 
      wangxiaohua@suda.edu.cn.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180523
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - China
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*diet therapy
MH  - *Diet, Carbohydrate-Restricted
MH  - *Diet, Diabetic
MH  - *Diet, Fat-Restricted
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage
MH  - Insulin/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - Time Factors
MH  - Treatment Outcome
MH  - Weight Loss
PMC - PMC6024764
OTO - NOTNLM
OT  - HbA1c
OT  - blood glucose
OT  - carbohydrate
OT  - diabetes mellitus
OT  - diet
OT  - fasting blood glucose
OT  - postprandial blood glucose
COIS- The authors declare no conflict of interest.
EDAT- 2018/06/09 06:00
MHDA- 2018/10/24 06:00
PMCR- 2018/06/01
CRDT- 2018/06/09 06:00
PHST- 2018/04/08 00:00 [received]
PHST- 2018/05/16 00:00 [revised]
PHST- 2018/05/17 00:00 [accepted]
PHST- 2018/06/09 06:00 [entrez]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2018/10/24 06:00 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - nu10060661 [pii]
AID - nutrients-10-00661 [pii]
AID - 10.3390/nu10060661 [doi]
PST - epublish
SO  - Nutrients. 2018 May 23;10(6):661. doi: 10.3390/nu10060661.