PMID- 29882950
OWN - NLM
STAT- MEDLINE
DCOM- 20190124
LR  - 20190124
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 10
IP  - 24
DP  - 2018 Jun 21
TI  - An easy-to-fabricate clearable CuS-superstructure-based multifunctional 
      theranostic platform for efficient imaging guided chemo-photothermal therapy.
PG  - 11430-11440
LID - 10.1039/c8nr03271h [doi]
AB  - Despite drug delivery systems (DDSs) receiving ever-increasing attention, 
      development of a simple, effective, sensitive and clearable drug delivery and 
      multifunctional theranostic nanoplatform for cancer therapy is still highly 
      desirable and remains a challenge. Herein, using a one-step solvothermal method, 
      hollow acanthosphere-like CuS superstructures assembled from  approximately 10 nm nanoparticles 
      (NPs) were successfully obtained and used as an efficient drug delivery and 
      theranostic platform for photoacoustic (PA) and infrared (IR) thermal 
      imaging-guided cancer combination therapy. The special hollow characteristic of 
      CuS superstructures with mesoporous shells and large cavities grants them high 
      drug loading capacity; they demonstrate near-infrared (NIR)/pH stimuli-sensitive 
      drug release and pronounced synergetic effects of chemo-photothermal therapy both 
      in vitro and in vivo. In particular, our as-fabricated hollow loose CuS 
      superstructures, with easily breakable characteristic, are biodegradable and able 
      to be cleared from the body when their therapy task is completed. This 
      CuS-superstructure-based clearable drug delivery and "all-in-one" cancer 
      theranostic platform might provide possibilities for improving therapeutic 
      efficacy and minimizing adverse effects.
FAU - Zhang, Wenlong
AU  - Zhang W
AD  - State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, 
      College of Materials Science and Engineering, Donghua University, Shanghai 
      201620, China. rjzou@dhu.edu.cn hu.junqing@dhu.edu.cn.
FAU - Xiao, Jingbo
AU  - Xiao J
FAU - Cao, Qing
AU  - Cao Q
FAU - Wang, Weiheng
AU  - Wang W
FAU - Peng, Xuan
AU  - Peng X
FAU - Guan, Guoqiang
AU  - Guan G
FAU - Cui, Zhe
AU  - Cui Z
FAU - Zhang, Yongfang
AU  - Zhang Y
FAU - Wang, Shige
AU  - Wang S
FAU - Zou, Rujia
AU  - Zou R
FAU - Wan, Xinjian
AU  - Wan X
FAU - Qiu, Huiling
AU  - Qiu H
FAU - Hu, Junqing
AU  - Hu J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 789U1901C5 (Copper)
RN  - 80168379AG (Doxorubicin)
RN  - KL4YU612X7 (cupric sulfide)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/administration & dosage
MH  - Copper/*chemistry
MH  - Doxorubicin/administration & dosage
MH  - *Drug Delivery Systems
MH  - HeLa Cells
MH  - Humans
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Nanoparticles
MH  - Neoplasms, Experimental/*diagnostic imaging/*drug therapy
MH  - Photoacoustic Techniques
MH  - *Photochemotherapy
MH  - Spectrophotometry, Infrared
MH  - *Theranostic Nanomedicine
EDAT- 2018/06/09 06:00
MHDA- 2019/01/25 06:00
CRDT- 2018/06/09 06:00
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2019/01/25 06:00 [medline]
PHST- 2018/06/09 06:00 [entrez]
AID - 10.1039/c8nr03271h [doi]
PST - ppublish
SO  - Nanoscale. 2018 Jun 21;10(24):11430-11440. doi: 10.1039/c8nr03271h.