PMID- 29883225
OWN - NLM
STAT- MEDLINE
DCOM- 20190326
LR  - 20190326
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 128
IP  - 12
DP  - 2018 Dec
TI  - Troxerutin cerebroprotein hydrolysate injection ameliorates neurovascular injury 
      induced by traumatic brain injury - via endothelial nitric oxide synthase pathway 
      regulation.
PG  - 1118-1127
LID - 10.1080/00207454.2018.1486828 [doi]
AB  - BACKGROUND: Neurovascular dysfunction caused by traumatic brain injury (TBI) is 
      characterized by cerebralvascular damage, blood-brain barrier (BBB) breakdown, 
      brain edema, etc. This study was designed to assess the protective role of 5 days 
      troxerutin cerebroprotein hydrolysate (TCH) injection treatment against TBI, as 
      well as the potential mechanism. METHODS: The weight-drop model of TBI in male 
      Sprague-Dawley rats was chosen to induce TBI model, rats either with TCH or a 
      vehicle via intraperitoneal injection were examined 3 days after TBI. RESULTS: 
      TCH resulted in alleviation of neurological deficits, reduction of infarct 
      volume, improvement of regional cerebral blood flow (rCBF), amelioration of 
      neuronal death, astrocyte proliferation, endothelial cell loss, and BBB 
      dysintegrity. These effects of TCH treatment against TBI were through endothelial 
      nitric oxide synthase (eNOS) coupling/decoupling status adjustment, which not 
      only increased nitric oxide (NO) level, but also decreased peroxynitrate level 
      expression. CONCLUSIONS: All the results indicated that TCH injection has 
      multifaceted protective effects of neurovascular unit (NVU) against TBI via eNOS 
      pathway regulation.
FAU - Zhao, Hongyi
AU  - Zhao H
AD  - a Department of Neurology , Army General Hospital of PLA , Beijing , PR China.
AD  - b Department of Neurology , No 261 Hospital of PLA , Beijing , PR China.
FAU - Liu, Yu
AU  - Liu Y
AD  - b Department of Neurology , No 261 Hospital of PLA , Beijing , PR China.
FAU - Zeng, Jing
AU  - Zeng J
AD  - a Department of Neurology , Army General Hospital of PLA , Beijing , PR China.
FAU - Li, Dandan
AU  - Li D
AD  - a Department of Neurology , Army General Hospital of PLA , Beijing , PR China.
FAU - Huang, Yonghua
AU  - Huang Y
AD  - a Department of Neurology , Army General Hospital of PLA , Beijing , PR China.
LA  - eng
PT  - Journal Article
DEP - 20181104
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Hydroxyethylrutoside)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Tight Junction Proteins)
RN  - 7Y4N11PXO8 (troxerutin)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
SB  - IM
MH  - Animals
MH  - Astrocytes/drug effects/metabolism
MH  - Blood-Brain Barrier/drug effects/pathology
MH  - Brain/blood supply/*drug effects
MH  - Brain Injuries, Traumatic/*drug therapy/*metabolism
MH  - Hydroxyethylrutoside/administration & dosage/*analogs & derivatives
MH  - Male
MH  - Neurons/drug effects/metabolism
MH  - Neuroprotective Agents/*administration & dosage
MH  - Nitric Oxide Synthase Type III/metabolism
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction
MH  - Tight Junction Proteins/metabolism
OTO - NOTNLM
OT  - Endothelial nitric oxide synthase
OT  - neurovascular unit
OT  - traumatic brain injury
OT  - troxerutin
EDAT- 2018/06/09 06:00
MHDA- 2019/03/27 06:00
CRDT- 2018/06/09 06:00
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2019/03/27 06:00 [medline]
PHST- 2018/06/09 06:00 [entrez]
AID - 10.1080/00207454.2018.1486828 [doi]
PST - ppublish
SO  - Int J Neurosci. 2018 Dec;128(12):1118-1127. doi: 10.1080/00207454.2018.1486828. 
      Epub 2018 Nov 4.