PMID- 29883542
OWN - NLM
STAT- MEDLINE
DCOM- 20190710
LR  - 20190710
IS  - 1526-4602 (Electronic)
IS  - 1525-7797 (Linking)
VI  - 19
IP  - 7
DP  - 2018 Jul 9
TI  - Tumor-pH-Sensitive PLLA-Based Microsphere with Acid Cleavable Acetal Bonds on the 
      Backbone for Efficient Localized Chemotherapy.
PG  - 3140-3148
LID - 10.1021/acs.biomac.8b00734 [doi]
AB  - Nanoparticle- and microsphere-based drug delivery systems (DDSs) have attracted 
      wide attention in cancer therapy; those DDSs that are responsive to tumor 
      environment can selectively identify tumor and normal tissues and therefore have 
      shown enhanced anticancer efficacy and alleviated systemic toxicity. Here, 
      tumor-pH-sensitive polymeric microspheres, which are prepared by multiblock 
      poly(l-lactide) with pH-sensitive acetal bonds in the backbone, are employed to 
      efficiently load water-soluble anticancer drug doxorubicin hydrochloride 
      (DOX.HCl, drug loading content:  approximately 10%). The pH-sensitive DOX-loaded hollow 
      microspheres were in the size range 2-10 mum and exhibited acid-accelerated 
      degradation of polymer matrix and drug release, and thereby efficient in vitro 
      cancer cell inhibition. The microspheres were further intratumorally injected 
      into breast-tumor-bearing mice, and the in vivo anticancer experiment showed that 
      pH-sensitive DOX-loaded microsphere showed better antitumor efficiency and 
      prolonged life-span than its counterpart that does not have pH-responsive 
      property. Moreover, negligible organ toxicity, especially cardiotoxicity that 
      generally exists in DOX-involved chemotherapy where DOX is administrated by 
      intravenous injection, was observed for DOX-loaded microspheres. Hence, 
      tumor-pH-sensitive polymeric microspheres have appeared to be a simple and 
      efficient platform for delivering hydrophilic anticancer drug with excellent 
      anticancer efficacy and low systemic toxicity.
FAU - Li, Junhua
AU  - Li J
AD  - National Engineering Research Center for Biomaterials , Sichuan University , 
      Chengdu 610064 , China.
FAU - Zhang, Xuequan
AU  - Zhang X
AD  - School of Chemical Engineering , Sichuan University , Chengdu 610065 , China.
FAU - Zhao, Mingying
AU  - Zhao M
AD  - School of Chemical Engineering , Sichuan University , Chengdu 610065 , China.
FAU - Wu, Lihuang
AU  - Wu L
AD  - National Engineering Research Center for Biomaterials , Sichuan University , 
      Chengdu 610064 , China.
FAU - Luo, Kui
AU  - Luo K
AUID- ORCID: 0000-0002-3536-1485
AD  - Huaxi MR Research Center (HMRRC), Department of Radiology , West China Hospital, 
      Sichuan University , Chengdu 610041 , China.
FAU - Pu, Yuji
AU  - Pu Y
AUID- ORCID: 0000-0002-4465-0262
AD  - National Engineering Research Center for Biomaterials , Sichuan University , 
      Chengdu 610064 , China.
FAU - He, Bin
AU  - He B
AD  - National Engineering Research Center for Biomaterials , Sichuan University , 
      Chengdu 610064 , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180621
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Polyesters)
RN  - 459TN2L5F5 (poly(lactide))
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage/adverse effects/pharmacokinetics
MH  - Cardiotoxicity
MH  - Cell Line
MH  - Cell Line, Tumor
MH  - Doxorubicin/administration & dosage/adverse effects/pharmacokinetics
MH  - Drug Carriers/*chemistry/pharmacokinetics
MH  - Drug Liberation
MH  - Hydrogen-Ion Concentration
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Microspheres
MH  - Polyesters/*chemistry
EDAT- 2018/06/09 06:00
MHDA- 2019/07/11 06:00
CRDT- 2018/06/09 06:00
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2019/07/11 06:00 [medline]
PHST- 2018/06/09 06:00 [entrez]
AID - 10.1021/acs.biomac.8b00734 [doi]
PST - ppublish
SO  - Biomacromolecules. 2018 Jul 9;19(7):3140-3148. doi: 10.1021/acs.biomac.8b00734. 
      Epub 2018 Jun 21.