PMID- 29883792
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20181024
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 547
IP  - 1-2
DP  - 2018 Aug 25
TI  - Potential of the association of dodecyl gallate with nanostructured lipid system 
      as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and 
      toxicity.
PG  - 630-636
LID - S0378-5173(18)30410-1 [pii]
LID - 10.1016/j.ijpharm.2018.06.013 [doi]
AB  - Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, 
      caused by Paracoccidioides spp. A limited number of antifungal agents are 
      available and the search for new compounds has increased. Additionally, 
      nanostructured lipid system (NLS) has emmerged as an interesting strategy to 
      carrier compounds for the treatment of mycosis. In this work, the antifungal 
      efficacy and toxicity of dodecyl gallate (DOD) associated with a NLS was 
      evaluated through in vitro and in vivo tests. DOD showed good in vitro antifungal 
      activity and low toxicity in lung fibroblasts and zebrafish embryos, but no 
      antifungal efficacy in infected mice, which may have been a result of low 
      bioavailability. On the other hand, the association of DOD + NLS was beneficial 
      and resulted in lower toxicity in lung fibroblasts and zebrafish embryos. In 
      addition, NLS + DOD promoted a significant reduction in the fungal burden of mice 
      lungs and could be a potential therapeutic option against PCM.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Singulani, Junya de Lacorte
AU  - Singulani JL
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - Scorzoni, Liliana
AU  - Scorzoni L
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - Lourencetti, Natalia Manuela Strohmayer
AU  - Lourencetti NMS
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - Oliveira, Luana Rossi
AU  - Oliveira LR
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - Concolaro, Rosana Silva
AU  - Concolaro RS
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - da Silva, Patricia Bento
AU  - da Silva PB
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - Nazare, Ana Carolina
AU  - Nazare AC
AD  - Sao Paulo State University (UNESP), Institute of Biosciences, Letters and Exact 
      Sciences, Sao Jose do Rio Preto, Sao Paulo, Brazil.
FAU - Polaquini, Carlos Roberto
AU  - Polaquini CR
AD  - Sao Paulo State University (UNESP), Institute of Biosciences, Letters and Exact 
      Sciences, Sao Jose do Rio Preto, Sao Paulo, Brazil.
FAU - Victorelli, Francesca Damiani
AU  - Victorelli FD
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - Chorilli, Marlus
AU  - Chorilli M
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - Regasini, Luis Octavio
AU  - Regasini LO
AD  - Sao Paulo State University (UNESP), Institute of Biosciences, Letters and Exact 
      Sciences, Sao Jose do Rio Preto, Sao Paulo, Brazil.
FAU - Fusco Almeida, Ana Marisa
AU  - Fusco Almeida AM
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil.
FAU - Mendes Giannini, Maria Jose Soares
AU  - Mendes Giannini MJS
AD  - Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, 
      Araraquara, Sao Paulo, Brazil. Electronic address: giannini@fcfar.unesp.br.
LA  - eng
PT  - Journal Article
DEP - 20180606
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Antifungal Agents)
RN  - 0 (Lipids)
RN  - 45612DY463 (lauryl gallate)
RN  - 632XD903SP (Gallic Acid)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/chemistry/*pharmacology/therapeutic use
MH  - Biological Availability
MH  - Cell Line
MH  - Disease Models, Animal
MH  - Female
MH  - Fibroblasts
MH  - Gallic Acid/*analogs & derivatives/chemistry/pharmacology/therapeutic use
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Lipids/chemistry
MH  - Lung/cytology/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nanoparticles/*chemistry
MH  - Paracoccidioides/*drug effects/isolation & purification
MH  - Paracoccidioidomycosis/*drug therapy/microbiology
MH  - Treatment Outcome
MH  - Zebrafish
OTO - NOTNLM
OT  - Antifungal compound
OT  - In vivo models
OT  - Lipid nanoparticles
OT  - Paracoccidioides sp.
OT  - Systemic mycosis
EDAT- 2018/06/09 06:00
MHDA- 2018/10/26 06:00
CRDT- 2018/06/09 06:00
PHST- 2018/01/29 00:00 [received]
PHST- 2018/05/28 00:00 [revised]
PHST- 2018/06/05 00:00 [accepted]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2018/06/09 06:00 [entrez]
AID - S0378-5173(18)30410-1 [pii]
AID - 10.1016/j.ijpharm.2018.06.013 [doi]
PST - ppublish
SO  - Int J Pharm. 2018 Aug 25;547(1-2):630-636. doi: 10.1016/j.ijpharm.2018.06.013. 
      Epub 2018 Jun 6.