PMID- 29883973
OWN - NLM
STAT- MEDLINE
DCOM- 20181008
LR  - 20220409
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 50
IP  - 6
DP  - 2018 Jun
TI  - Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type 2 Diabetes 
      Mellitus and Metabolic Syndrome: A Systematic Review and Meta-Analysis.
PG  - 469-477
LID - 10.1055/a-0620-8553 [doi]
AB  - The associations between PvuII (T>C) and XbaI (A>G) polymorphisms of estrogen 
      receptor alpha (ESR1) gene with type 2 diabetes mellitus (T2DM) or metabolic 
      syndrome (MetS) are reported in many studies, but the results are inconsistent. 
      This present work aims to assess the associations by performing a comprehensive 
      meta-analysis. Relevant studies were searched through several databases. The 
      pooled odd ratios (ORs) with 95% confidence intervals (CIs) were calculated to 
      evaluate the associations of PvuII and XbaI polymorphisms with the risk of T2DM 
      and MetS by using the STATA 14.0 software. Eight studies for T2DM and three 
      articles about MetS were included in this meta-analysis. The overall results 
      indicated that PvuII, rather than XbaI polymorphism, was associated with T2DM 
      (regressive model: OR=0.673, 95% CI=0.550 to 0.823, p(raw)<0.001, p(FDR)<0.003). 
      The subgroup analysis based on race revealed an association of PvuII polymorphism 
      with the decreased T2DM risk in Chinese population and a relationship between 
      XbaI polymorphism and the reduced T2DM susceptibility in Caucasians. The 
      difference of country may be one source of the heterogeneity for PvuII 
      polymorphism and T2DM. However, neither PvuII nor XbaI polymorphism was related 
      to the risk of MetS. The C allele of PvuII polymorphism presents a protective 
      role in T2DM risk, especially in Chinese people. The G allele of XbaI 
      polymorphism is related to a reduced risk for T2DM in Caucasian population. 
      Nevertheless, neither of PvuII nor XbaI polymorphism is associated with MetS 
      risk.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Yang, Jiajia
AU  - Yang J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Han, Renfang
AU  - Han R
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Chen, Mengya
AU  - Chen M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Yuan, Yaping
AU  - Yuan Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Hu, Xingxing
AU  - Hu X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Ma, Yubo
AU  - Ma Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Wu, Meng
AU  - Wu M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Wang, Mengmeng
AU  - Wang M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
FAU - Jiang, Shanqun
AU  - Jiang S
AD  - School of Life Sciences, Anhui University, Hefei, Anhui, China.
FAU - Pan, Faming
AU  - Pan F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
AD  - The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 
      Anhui, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20180608
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Estrogen Receptor alpha/*genetics
MH  - *Genetic Association Studies
MH  - Genetic Heterogeneity
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Metabolic Syndrome/*genetics
MH  - *Polymorphism, Genetic
MH  - Publication Bias
COIS- The authors declare they have no conflict of interest.
EDAT- 2018/06/09 06:00
MHDA- 2018/10/09 06:00
CRDT- 2018/06/09 06:00
PHST- 2018/06/09 06:00 [entrez]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2018/10/09 06:00 [medline]
AID - 10.1055/a-0620-8553 [doi]
PST - ppublish
SO  - Horm Metab Res. 2018 Jun;50(6):469-477. doi: 10.1055/a-0620-8553. Epub 2018 Jun 
      8.