PMID- 29884618
OWN - NLM
STAT- MEDLINE
DCOM- 20190403
LR  - 20190403
IS  - 2470-9468 (Electronic)
IS  - 2470-9468 (Linking)
VI  - 3
IP  - 24
DP  - 2018 Jun 8
TI  - CD4(+) T cell-mediated HLA class II cross-restriction in HIV controllers.
LID - eaat0687 [pii]
LID - 10.1126/sciimmunol.aat0687 [doi]
AB  - Rare individuals, termed HIV controllers, spontaneously control HIV infection by 
      mounting efficient T cell responses against the virus. Protective CD4(+) T cell 
      responses from HIV controllers involve high-affinity public T cell receptors 
      (TCRs) recognizing an immunodominant capsid epitope (Gag293) presented by a 
      remarkably broad array of human leukocyte antigen (HLA) class II molecules. Here, 
      we determine the structures of a prototypical public TCR bound to HLA-DR1, 
      HLA-DR11, and HLA-DR15 molecules presenting the Gag293 epitope. TCR recognition 
      was driven by contacts with the Gag293 epitope, a feature that underpinned the 
      extensive HLA cross-restriction. These high-affinity TCRs promoted mature 
      immunological synapse formation and cytotoxic capacity in both CD4(+) and CD8(+) 
      T cells. The public TCRs suppressed HIV replication in multiple genetic 
      backgrounds ex vivo, emphasizing the functional advantage conferred by broad HLA 
      class II cross-restriction.
CI  - Copyright (c) 2018 The Authors, some rights reserved; exclusive licensee American 
      Association for the Advancement of Science. No claim to original U.S. Government 
      Works.
FAU - Galperin, Moran
AU  - Galperin M
AUID- ORCID: 0000-0003-4406-763X
AD  - Pasteur Institute, Viral Pathogenesis Unit, Paris, France.
FAU - Farenc, Carine
AU  - Farenc C
AUID- ORCID: 0000-0001-6383-3032
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 
      3800, Australia.
FAU - Mukhopadhyay, Madhura
AU  - Mukhopadhyay M
AD  - Pasteur Institute, Viral Pathogenesis Unit, Paris, France.
FAU - Jayasinghe, Dhilshan
AU  - Jayasinghe D
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 
      3800, Australia.
FAU - Decroos, Amandine
AU  - Decroos A
AD  - Pasteur Institute, Viral Pathogenesis Unit, Paris, France.
FAU - Benati, Daniela
AU  - Benati D
AUID- ORCID: 0000-0002-6599-7193
AD  - Pasteur Institute, Viral Pathogenesis Unit, Paris, France.
FAU - Tan, Li Lynn
AU  - Tan LL
AUID- ORCID: 0000-0003-0606-4446
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 
      3800, Australia.
FAU - Ciacchi, Lisa
AU  - Ciacchi L
AUID- ORCID: 0000-0001-9130-7718
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 
      3800, Australia.
FAU - Reid, Hugh H
AU  - Reid HH
AUID- ORCID: 0000-0001-6929-5001
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 
      3800, Australia.
AD  - ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, 
      Clayton, Victoria 3800, Australia.
FAU - Rossjohn, Jamie
AU  - Rossjohn J
AUID- ORCID: 0000-0002-2020-7522
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 
      3800, Australia.
AD  - ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, 
      Clayton, Victoria 3800, Australia.
AD  - Institute of Infection and Immunity, School of Medicine, Cardiff University, 
      Cardiff CF14 4XN, UK.
FAU - Chakrabarti, Lisa A
AU  - Chakrabarti LA
AUID- ORCID: 0000-0002-1895-3630
AD  - Pasteur Institute, Viral Pathogenesis Unit, Paris, France.
AD  - INSERM, U1108, Paris, France.
FAU - Gras, Stephanie
AU  - Gras S
AUID- ORCID: 0000-0001-7416-038X
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 
      3800, Australia.
AD  - ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, 
      Clayton, Victoria 3800, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Sci Immunol
JT  - Science immunology
JID - 101688624
RN  - 0 (HLA-D Antigens)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Cross Reactions/immunology
MH  - Fibroblasts
MH  - HEK293 Cells
MH  - HIV Infections/*immunology
MH  - HIV-1/*immunology
MH  - HLA-D Antigens/*immunology
MH  - Healthy Volunteers
MH  - Host-Pathogen Interactions/*immunology
MH  - Humans
MH  - Jurkat Cells
MH  - Leukocytes, Mononuclear
MH  - Lymphocyte Activation
MH  - Mice
MH  - Primary Cell Culture
MH  - Receptors, Antigen, T-Cell/immunology
MH  - Viral Load/immunology
MH  - Virus Replication/immunology
EDAT- 2018/06/10 06:00
MHDA- 2019/04/04 06:00
CRDT- 2018/06/10 06:00
PHST- 2018/01/21 00:00 [received]
PHST- 2018/04/18 00:00 [accepted]
PHST- 2018/06/10 06:00 [entrez]
PHST- 2018/06/10 06:00 [pubmed]
PHST- 2019/04/04 06:00 [medline]
AID - 3/24/eaat0687 [pii]
AID - 10.1126/sciimmunol.aat0687 [doi]
PST - ppublish
SO  - Sci Immunol. 2018 Jun 8;3(24):eaat0687. doi: 10.1126/sciimmunol.aat0687.