PMID- 29885105
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 42
IP  - 4
DP  - 2018 Aug
TI  - Insulin Resistance and the Risk of Diabetes and Dysglycemia in Korean General 
      Adult Population.
PG  - 296-307
LID - 10.4093/dmj.2017.0106 [doi]
AB  - BACKGROUND: Insulin resistance is a major pathogenic hallmark of impaired glucose 
      metabolism. We assessed the accuracy of insulin resistance and cut-off values 
      using homeostasis model assessment of insulin resistance (HOMA-IR) to classify 
      type 2 diabetes mellitus (T2DM) and dysglycemia according to age and sex. 
      METHODS: In this cross-sectional study, we analyzed 4,291 anti-diabetic 
      drug-naive adults (>/=20 years) from the 6th Korea National Health and Nutrition 
      Examination Survey in 2015. Metabolic syndrome (MetS) was defined by the modified 
      National Cholesterol Education Program III guideline. Diagnosis of dysglycemia 
      and T2DM were based on fasting glucose and glycosylated hemoglobin levels. The 
      receiver operating characteristic curve and optimal cut-off values of HOMA-IR 
      were assessed to identify T2DM/dysglycemia according to sex and were further 
      analyzed by age. RESULTS: Sex differences were found in the association of MetS 
      and the different MetS components with T2DM/dysglycemia. The overall optimal 
      cut-off value of HOMA-IR for identifying dysglycemia was 1.6 in both sex. The 
      cut-off values for T2DM were 2.87 in men and 2.36 in women. However, there are 
      differences in diagnostic range of HOMA-IR to distinguish T2DM according to sex 
      and age, and the accuracy of HOMA-IR in identifying T2DM gradually decreased with 
      age especially in women. CONCLUSION: Insulin resistance is closely associated 
      with the risk for T2DM/dysglycemia. The accuracy of HOMA-IR levels is 
      characterized by sex- and age-specific differences in identifying T2DM. In 
      addition to insulin resistance index, insulin secretory function, and different 
      MetS components should be considered in the detection of early T2DM, especially 
      in elderly.
CI  - Copyright (c) 2018 Korean Diabetes Association.
FAU - Baek, Jong Ha
AU  - Baek JH
AD  - Department of Internal Medicine, Gyeongsang National University Changwon 
      Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
FAU - Kim, Hosu
AU  - Kim H
AD  - Department of Internal Medicine, Gyeongsang National University Changwon 
      Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
FAU - Kim, Kyong Young
AU  - Kim KY
AD  - Department of Internal Medicine, Gyeongsang National University Changwon 
      Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
FAU - Jung, Jaehoon
AU  - Jung J
AUID- ORCID: 0000-0002-5444-1229
AD  - Department of Internal Medicine, Gyeongsang National University Changwon 
      Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
AD  - Institute of Health Science, Gyeongsang National University School of Medicine, 
      Jinju, Korea. taesikjung@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180424
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC6107354
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Hyperglycemia
OT  - Insulin resistance
OT  - Risk
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2018/06/10 06:00
MHDA- 2018/06/10 06:01
PMCR- 2018/08/01
CRDT- 2018/06/10 06:00
PHST- 2017/12/27 00:00 [received]
PHST- 2018/03/02 00:00 [accepted]
PHST- 2018/06/10 06:00 [pubmed]
PHST- 2018/06/10 06:01 [medline]
PHST- 2018/06/10 06:00 [entrez]
PHST- 2018/08/01 00:00 [pmc-release]
AID - 42.e12 [pii]
AID - 10.4093/dmj.2017.0106 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2018 Aug;42(4):296-307. doi: 10.4093/dmj.2017.0106. Epub 2018 
      Apr 24.