PMID- 29885106
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 42
IP  - 3
DP  - 2018 Jun
TI  - Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic 
      Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats.
PG  - 244-248
LID - 10.4093/dmj.2018.0002 [doi]
AB  - Due to the multifactorial and multisystemic nature of diabetes mellitus, it is 
      often treated with a combination of therapeutic agents having different mode of 
      action. Earlier, we have synthesized several organozinc complexes and evaluated 
      their safety and antidiabetic properties in experimental type 2 diabetes mellitus 
      (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex 
      and studied its antidiabetic efficacy in experimental rats. In the present study, 
      a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, 
      characterized by spectral studies and its antidiabetic properties was evaluated 
      in HFD fed-low dose streptozotocin induced T2DM in rats. The hypoglycemic 
      efficacy of the complex was evaluated through oral glucose tolerance test, 
      homeostasis model assessment of insulin resistance, quantitative insulin 
      sensitivity check index and by determining the status of important biochemical 
      parameters. Oral administration of the complex at a concentration of 10 mg/kg 
      body weight/rat/day for 30 days significantly improved the glucose homeostasis. 
      The complex possesses significant antidiabetic properties relatively at a less 
      concentration than metformin-3-hydroxyflavone complex in ameliorating 
      hyperglycemia.
CI  - Copyright (c) 2018 Korean Diabetes Association.
FAU - Koothappan, Muruganantham
AU  - Koothappan M
AD  - Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
FAU - Vellai, Roshana Devi
AU  - Vellai RD
AD  - Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
FAU - Subramanian, Iyyam Pillai
AU  - Subramanian IP
AD  - PG and Research Department of Chemistry, Pachaiyappa's College, Chennai, India.
FAU - Subramanian, Sorimuthu Pillai
AU  - Subramanian SP
AUID- ORCID: 0000-0001-5137-3956
AD  - Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India. 
      subbus2020@yahoo.co.in.
LA  - eng
PT  - Journal Article
DEP - 20180424
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC6015968
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Hypoglycemic agents
OT  - Metformin
OT  - Rats
OT  - Zinc
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2018/06/10 06:00
MHDA- 2018/06/10 06:01
PMCR- 2018/06/01
CRDT- 2018/06/10 06:00
PHST- 2018/01/03 00:00 [received]
PHST- 2018/02/20 00:00 [accepted]
PHST- 2018/06/10 06:00 [pubmed]
PHST- 2018/06/10 06:01 [medline]
PHST- 2018/06/10 06:00 [entrez]
PHST- 2018/06/01 00:00 [pmc-release]
AID - 42.e13 [pii]
AID - 10.4093/dmj.2018.0002 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2018 Jun;42(3):244-248. doi: 10.4093/dmj.2018.0002. Epub 2018 
      Apr 24.