PMID- 29885344
OWN - NLM
STAT- MEDLINE
DCOM- 20190723
LR  - 20190723
IS  - 1872-8111 (Electronic)
IS  - 0168-0102 (Linking)
VI  - 143
DP  - 2019 Jun
TI  - Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in 
      Alzheimer's disease model mouse.
PG  - 61-70
LID - S0168-0102(18)30202-5 [pii]
LID - 10.1016/j.neures.2018.06.002 [doi]
AB  - Cerebral neuroinflammation defines a novel pathway for progressing Alzheimer's 
      disease (AD) pathology. We investigated immunohistological changes of 
      neuroinflammation with nucleotide-binding domain and leucine-rich repeat 
      (NLR)-protein 3 (NLRP3), activated caspase-1 and interleukin-1 beta (IL-1beta) in a 
      novel AD (APP23) mice with chronic cerebral hypoperfusion (CCH) model from 4 
      months (M) of age, moreover, examined protective effect of galantamine. CCH 
      strongly enhanced NLRP3, activated caspase-1 and IL-1beta expressions in hippocampus 
      and thalamus at age 12 M of AD mice. CCH also exaggerated amyloid-beta (Abeta) 40 
      depositions in cerebral cortex. Furthermore, CCH exacerbated a marked 
      dissociation of neurovascular unit (NVU). These pathological changes were 
      ameliorated by galantamine treatment. The present study demonstrated that CCH 
      strongly enhanced primary AD pathology including neuroinflammation, Abeta 
      accumulations and NVU dissociation in AD mice, which was greatly protected by an 
      allosterically potentiating ligand galantamine.
CI  - Copyright (c) 2018 Elsevier B.V. and Japan Neuroscience Society. All rights 
      reserved.
FAU - Shang, Jingwei
AU  - Shang J
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Yamashita, Toru
AU  - Yamashita T
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Zhai, Yun
AU  - Zhai Y
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Nakano, Yumiko
AU  - Nakano Y
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Morihara, Ryuta
AU  - Morihara R
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Li, Xianghong
AU  - Li X
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Tian, Feng
AU  - Tian F
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Liu, Xia
AU  - Liu X
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Huang, Yong
AU  - Huang Y
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Shi, Xiaowen
AU  - Shi X
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Sato, Kota
AU  - Sato K
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Takemoto, Mami
AU  - Takemoto M
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Hishikawa, Nozomi
AU  - Hishikawa N
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Ohta, Yasuyuki
AU  - Ohta Y
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan.
FAU - Abe, Koji
AU  - Abe K
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 
      700-8558, Japan. Electronic address: p4wi2ykv@okayama-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20180606
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 0D3Q044KCA (Galantamine)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.4.22.36 (Casp1 protein, mouse)
RN  - EC 3.4.22.36 (Caspase 1)
MH  - Alzheimer Disease/*metabolism/*pathology
MH  - Amyloid beta-Peptides/metabolism
MH  - Animals
MH  - Brain Ischemia/metabolism/pathology
MH  - Caspase 1/metabolism
MH  - Cerebral Cortex/metabolism/pathology
MH  - Cerebrovascular Circulation/*physiology
MH  - Collagen/metabolism
MH  - Disease Models, Animal
MH  - Galantamine/pharmacology
MH  - Inflammasomes/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
MH  - Neurons/drug effects/pathology
MH  - Neuroprotective Agents/pharmacology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Chronic cerebral hypoperfusion
OT  - Galantamine
OT  - Neuroinflammation
OT  - Neurovascular unit dissociation
EDAT- 2018/06/10 06:00
MHDA- 2019/07/25 06:00
CRDT- 2018/06/10 06:00
PHST- 2018/04/08 00:00 [received]
PHST- 2018/05/27 00:00 [revised]
PHST- 2018/06/04 00:00 [accepted]
PHST- 2018/06/10 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2018/06/10 06:00 [entrez]
AID - S0168-0102(18)30202-5 [pii]
AID - 10.1016/j.neures.2018.06.002 [doi]
PST - ppublish
SO  - Neurosci Res. 2019 Jun;143:61-70. doi: 10.1016/j.neures.2018.06.002. Epub 2018 
      Jun 6.