PMID- 29885537
OWN - NLM
STAT- MEDLINE
DCOM- 20180822
LR  - 20230310
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Print)
IS  - 1568-9972 (Linking)
VI  - 17
IP  - 8
DP  - 2018 Aug
TI  - Impact of obesity on autoimmune arthritis and its cardiovascular complications.
PG  - 821-835
LID - S1568-9972(18)30129-0 [pii]
LID - 10.1016/j.autrev.2018.02.007 [doi]
AB  - Obesity can instigate and sustain a systemic low-grade inflammatory environment 
      that can amplify autoimmune disorders and their associated comorbidities. 
      Metabolic changes and inflammatory factors produced by the adipose tissue have 
      been reported to aggravate autoimmunity and predispose the patient to 
      cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis 
      (RA) and psoriatic arthritis (PsA) are autoimmune arthritic diseases, often 
      linked with altered body mass index (BMI). Severe joint inflammation and bone 
      destruction have a debilitating impact on the patient's life; there is also a 
      staggering risk of cardiovascular morbidity and mortality. Furthermore, these 
      patients are at risk of developing metabolic symptoms, including insulin 
      resistance resulting in type 2 diabetes mellitus (T2DM). In addition, arthritis 
      severity, progression and response to therapy can be markedly affected by the 
      patient's BMI. Hence, a complex integrative pathogenesis interconnects 
      autoimmunity with metabolic and cardiovascular disorders. This review aims to 
      shed light on the network that connects obesity with RA, PsA, systemic lupus 
      erythematosus and Sjӧgren's syndrome. We have focused on clarifying the mechanism 
      by which obesity affects different cell types, inflammatory factors and 
      traditional therapies in these autoimmune disorders. We conclude that to further 
      optimize arthritis therapy and to prevent CVD, it is imperative to uncover the 
      intricate relation between obesity and arthritis pathology.
CI  - Published by Elsevier B.V.
FAU - Van Raemdonck, Katrien
AU  - Van Raemdonck K
AD  - Jesse Brown VA Medical Center, Chicago, IL 60612, United States; Department of 
      Medicine, Division of Rheumatology, University of Illinois at Chicago, IL 60612, 
      United States.
FAU - Umar, Sadiq
AU  - Umar S
AD  - Jesse Brown VA Medical Center, Chicago, IL 60612, United States; Department of 
      Medicine, Division of Rheumatology, University of Illinois at Chicago, IL 60612, 
      United States.
FAU - Szekanecz, Zoltan
AU  - Szekanecz Z
AD  - Department of Rheumatology, Institute of Medicine, University of Debrecen Faculty 
      of Medicine, Nagyerdei Str 98, Debrecen H-4004, Hungary.
FAU - Zomorrodi, Ryan K
AU  - Zomorrodi RK
AD  - Department of Medicine, Division of Rheumatology, University of Illinois at 
      Chicago, IL 60612, United States.
FAU - Shahrara, Shiva
AU  - Shahrara S
AD  - Jesse Brown VA Medical Center, Chicago, IL 60612, United States; Department of 
      Medicine, Division of Rheumatology, University of Illinois at Chicago, IL 60612, 
      United States. Electronic address: shahrara@uic.edu.
LA  - eng
GR  - I01 BX002286/BX/BLRD VA/United States
GR  - R03 AR065778/AR/NIAMS NIH HHS/United States
GR  - R41 AI147697/AI/NIAID NIH HHS/United States
GR  - R43 AG057312/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20180606
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Arthritis, Rheumatoid/*etiology
MH  - Autoimmune Diseases/*etiology
MH  - Cardiovascular Diseases/*etiology
MH  - Humans
MH  - Obesity/*complications
PMC - PMC9996646
MID - NIHMS1878177
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Inflammation
OT  - Metabolic syndrome
OT  - Obesity
OT  - PsA
OT  - RA
COIS- DISCLOSURE There is no conflict of interest to be disclosed.
EDAT- 2018/06/10 06:00
MHDA- 2018/08/23 06:00
PMCR- 2023/03/09
CRDT- 2018/06/10 06:00
PHST- 2018/02/20 00:00 [received]
PHST- 2018/02/25 00:00 [accepted]
PHST- 2018/06/10 06:00 [pubmed]
PHST- 2018/08/23 06:00 [medline]
PHST- 2018/06/10 06:00 [entrez]
PHST- 2023/03/09 00:00 [pmc-release]
AID - S1568-9972(18)30129-0 [pii]
AID - 10.1016/j.autrev.2018.02.007 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2018 Aug;17(8):821-835. doi: 10.1016/j.autrev.2018.02.007. Epub 
      2018 Jun 6.