PMID- 29885788
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20211204
IS  - 1938-0666 (Electronic)
IS  - 1526-8209 (Linking)
VI  - 18
IP  - 5
DP  - 2018 Oct
TI  - Association of Allelic Interaction of Single Nucleotide Polymorphisms of Influx 
      and Efflux Transporters Genes With Nonhematologic Adverse Events of Docetaxel in 
      Breast Cancer Patients.
PG  - e1173-e1179
LID - S1526-8209(17)30628-6 [pii]
LID - 10.1016/j.clbc.2018.04.018 [doi]
AB  - PURPOSE: Nonhematologic adverse events (AEs) of docetaxel constitute an extra 
      burden in the treatment of cancer patients and necessitate either a dose 
      reduction or an outright switch of docetaxel for other regimens. These AEs are 
      frequently associated with genetic polymorphisms of genes encoding for proteins 
      involved docetaxel disposition. Therefore, we investigated that association in 
      Malaysian breast cancer patients. MATERIALS AND METHODS: A total of 110 Malaysian 
      breast cancer patients were enrolled in the present study, and their blood 
      samples were investigated for different single nucleotide polymorphisms using 
      polymerase chain reaction restriction fragment length polymorphism. AEs were 
      evaluated using the Common Terminology Criteria for Adverse Events, version 4.0. 
      RESULTS: Fatigue, nausea, oral mucositis, and vomiting were the most common 
      nonhematologic AEs. Rash was associated with heterozygous and mutant genotypes of 
      ABCB1 3435C>T (P < .05). Moreover, patients carrying the GG genotype of ABCB1 
      2677G>A/T reported more fatigue than those carrying the heterozygous genotype GA 
      (P < .05). The presence of ABCB1 3435-T, ABCC2 3972-C, ABCC2 1249-G, and ABCB1 
      2677-G alleles was significantly associated with nausea and oral mucositis. The 
      coexistence of ABCB1 3435-C, ABCC2 3972-C, ABCC2 1249-G, and ABCB1 2677-A was 
      significantly associated with vomiting (P < .05). CONCLUSION: The prevalence of 
      nonhematologic AEs in breast cancer patients treated with docetaxel has been 
      relatively high. The variant allele of ABCB1 3435C>T polymorphism could be a 
      potential predictive biomarker of docetaxel-induced rash, and homozygous 
      wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue. In 
      addition, the concurrent presence of specific alleles could be predictive of 
      vomiting, nausea, and oral mucositis.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Jabir, Rafid Salim
AU  - Jabir RS
AD  - Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health 
      Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
FAU - Ho, Gwo Fuang
AU  - Ho GF
AD  - Clinical Oncology Unit, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
FAU - Annuar, Muhammad Azrif Bin Ahmad
AU  - Annuar MABA
AD  - Department of Radiotherapy and Oncology, Universiti Kebangsaan Malaysia Medical 
      Centre, Jalan Yaacob Latif, Kuala Lumpur, Malaysia.
FAU - Stanslas, Johnson
AU  - Stanslas J
AD  - Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health 
      Sciences, Universiti Putra Malaysia, Selangor, Malaysia. Electronic address: 
      rcxjs@upm.edu.my.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180504
PL  - United States
TA  - Clin Breast Cancer
JT  - Clinical breast cancer
JID - 100898731
RN  - 0 (ABCB1 protein, human)
RN  - 0 (ABCC2 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Multidrug Resistance-Associated Protein 2)
RN  - 0 (Multidrug Resistance-Associated Proteins)
RN  - 15H5577CQD (Docetaxel)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B/genetics
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/*adverse effects
MH  - Breast Neoplasms/*drug therapy
MH  - Docetaxel/*adverse effects
MH  - Drug-Related Side Effects and Adverse Reactions/genetics
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Multidrug Resistance-Associated Protein 2
MH  - Multidrug Resistance-Associated Proteins/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Prospective Studies
OTO - NOTNLM
OT  - ABCB1
OT  - ABCC2
OT  - Pharmacogenetics
OT  - SLCO1B3
OT  - SNPs
EDAT- 2018/06/11 06:00
MHDA- 2019/07/16 06:00
CRDT- 2018/06/11 06:00
PHST- 2017/09/22 00:00 [received]
PHST- 2018/02/19 00:00 [revised]
PHST- 2018/04/23 00:00 [accepted]
PHST- 2018/06/11 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2018/06/11 06:00 [entrez]
AID - S1526-8209(17)30628-6 [pii]
AID - 10.1016/j.clbc.2018.04.018 [doi]
PST - ppublish
SO  - Clin Breast Cancer. 2018 Oct;18(5):e1173-e1179. doi: 10.1016/j.clbc.2018.04.018. 
      Epub 2018 May 4.