PMID- 29885811
OWN - NLM
STAT- MEDLINE
DCOM- 20190201
LR  - 20190201
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 23
DP  - 2018 Sep
TI  - Long-term clinical outcome in patients with high-grade soft tissue sarcoma who 
      were treated with surgical adjuvant therapy using acridine orange after 
      intra-lesional or marginal resection.
PG  - 165-170
LID - S1572-1000(18)30082-6 [pii]
LID - 10.1016/j.pdpdt.2018.06.001 [doi]
AB  - BACKGROUND: We investigated the long-term clinical efficacy of acridine orange 
      (AO) therapy on the inhibition of local recurrence after marginal or 
      intra-lesional tumor resection in high-grade soft tissue sarcomas (STSs). 
      METHODS: Our study consisted of 48 patients with STSs who received AO therapy 
      after marginal or intra-lesional resection. The median and mean follow-up 
      durations were 76 and 78 months, respectively. Our AO therapy procedure was 
      combined with photodynamic surgery, photodynamic therapy, and radiodynamic 
      therapy. RESULTS: There were 25 men and 23 women, with a mean age of 46 years. 
      The average tumor size at surgery was 8.5 cm. At the last follow-up, 11 patients 
      developed local recurrence. The 5- and 10-year local recurrence-free rates were 
      78.9% and 73.3%, respectively. In multivariate analysis, tumor size remained 
      significant for local control. None of the patients developed systemic or local 
      complications. All patients recovered activities of daily life before AO therapy. 
      CONCLUSION: AO therapy can be performed in safety and may be a useful therapy for 
      acquiring long-term local control in patients with high-grade STSs. Tumor size is 
      an important factor for the indication of AO therapy.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Nakamura, Tomoki
AU  - Nakamura T
AD  - Department of Orthopaedic Surgery, Mie University Postgraduate School of 
      Medicine, Edobashi 2-174, Tsu-city, 514-8507, Japan. Electronic address: 
      tomoki66@clin.medic.mie-u.ac.jp.
FAU - Kusuzaki, Katsuyuki
AU  - Kusuzaki K
AD  - Department of Musculoskeletal Oncology, Takai Hospital, Kuranosho 470-8, Tenri, 
      632-0006, Japan.
FAU - Matsubara, Takao
AU  - Matsubara T
AD  - Matsubara Orthopaedic Clinic. Shiroyama 3-4-25, Tsu-city, 514-0818, Japan.
FAU - Murata, Hiroaki
AU  - Murata H
AD  - Department of Orthopaedic Surgery, Matsushita Memorial Hospital, Moriguchi-City, 
      570-8540, Japan.
FAU - Hagi, Tomohito
AU  - Hagi T
AD  - Department of Orthopaedic Surgery, Mie University Postgraduate School of 
      Medicine, Edobashi 2-174, Tsu-city, 514-8507, Japan.
FAU - Asanuma, Kunihiro
AU  - Asanuma K
AD  - Department of Orthopaedic Surgery, Mie University Postgraduate School of 
      Medicine, Edobashi 2-174, Tsu-city, 514-8507, Japan.
FAU - Sudo, Akihiro
AU  - Sudo A
AD  - Department of Orthopaedic Surgery, Mie University Postgraduate School of 
      Medicine, Edobashi 2-174, Tsu-city, 514-8507, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180607
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*administration & dosage
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Margins of Excision
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Photochemotherapy/*methods
MH  - Photosensitizing Agents/*administration & dosage
MH  - Sarcoma/*drug therapy
MH  - Soft Tissue Neoplasms/*drug therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Acridine orange
OT  - Local control
OT  - Photodynamic therapy
OT  - Radiodymanic therapy
OT  - Soft tissue sarcoma
EDAT- 2018/06/11 06:00
MHDA- 2019/02/02 06:00
CRDT- 2018/06/11 06:00
PHST- 2018/03/15 00:00 [received]
PHST- 2018/06/01 00:00 [revised]
PHST- 2018/06/01 00:00 [accepted]
PHST- 2018/06/11 06:00 [pubmed]
PHST- 2019/02/02 06:00 [medline]
PHST- 2018/06/11 06:00 [entrez]
AID - S1572-1000(18)30082-6 [pii]
AID - 10.1016/j.pdpdt.2018.06.001 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2018 Sep;23:165-170. doi: 
      10.1016/j.pdpdt.2018.06.001. Epub 2018 Jun 7.