PMID- 29886075
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20190715
IS  - 1532-821X (Electronic)
IS  - 0003-9993 (Linking)
VI  - 99
IP  - 12
DP  - 2018 Dec
TI  - A High-Intensity Multicomponent Agility Intervention Improves Parkinson Patients' 
      Clinical and Motor Symptoms.
PG  - 2478-2484.e1
LID - S0003-9993(18)30353-8 [pii]
LID - 10.1016/j.apmr.2018.05.007 [doi]
AB  - OBJECTIVE: To determine the effects of a high-intensity exercise therapy using 
      sensorimotor and visual stimuli on nondemented Parkinson disease (PD) patients' 
      clinical symptoms, mobility, and standing balance. DESIGN: Randomized clinical 
      intervention, using a before-after trial design. SETTING: University hospital 
      setting. PARTICIPANTS: A total of 72 PD patients with Hoehn and Yahr stage of 
      2-3, of whom 64 were randomized, and 55 completed the study. INTERVENTION: PD 
      patients were randomly assigned to a no physical intervention control (n=20 of 29 
      completed, 9 withdrew before baseline testing) or to a high-intensity agility 
      program (15 sessions, 3 weeks, n=35 completed). MAIN OUTCOME MEASURES: Primary 
      outcome was the Movement Disorders Society-Unified Parkinson Disease Rating Scale 
      (MDS-UPDRS) motor experiences of daily living (M-EDL). Secondary outcomes were 
      Beck Depression score, Parkinson Disease Questionnaire-39 (PDQ-39), EuroQoL 
      Five-Dimension (EQ5D) Questionnaire visual analog scale, Schwab and England 
      Activities of Daily Living (SE ADL) Scale, timed Up and Go (TUG) test, and 12 
      measures of static posturography. RESULTS: The agility program improved MDS-UPDRS 
      M-EDL by 38% compared with the 2% change in control (group by time interaction, 
      P=.001). Only the intervention group improved in PDQ-39 (6.6 points), depression 
      (18%), EQ5D visual analog scale score (15%), the SE ADL Scale score (15%), the 
      TUG test (39%), and in 8 of 12 posturography measures by 42%-55% (all P<.001). 
      The levodopa equivalent dosage did not change. CONCLUSION: A high-intensity 
      agility program improved nondemented, stage 2-3 PD patients' clinical symptoms, 
      mobility, and standing balance by functionally meaningful margins at short-term 
      follow-up.
CI  - Copyright (c) 2018 American Congress of Rehabilitation Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Tollar, Jozsef
AU  - Tollar J
AD  - Somogy County Kaposi Mor Teaching Hospital, Kaposvar, Hungary. Electronic 
      address: tollarjozsef86@gmail.com.
FAU - Nagy, Ferenc
AU  - Nagy F
AD  - Somogy County Kaposi Mor Teaching Hospital, Kaposvar, Hungary.
FAU - Kovacs, Norbert
AU  - Kovacs N
AD  - Department of Neurology Clinic, University of Pecs, Pecs, Hungary; MTA-PTE 
      Clinical Neuroscience MR Research Group, Pecs, Hungary.
FAU - Hortobagyi, Tibor
AU  - Hortobagyi T
AD  - University of Groningen, University Medical Center Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180607
PL  - United States
TA  - Arch Phys Med Rehabil
JT  - Archives of physical medicine and rehabilitation
JID - 2985158R
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Disability Evaluation
MH  - Exercise Therapy/*methods
MH  - *Feedback, Sensory
MH  - Female
MH  - Humans
MH  - Levodopa/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Mobility Limitation
MH  - Motor Skills/*physiology
MH  - Movement
MH  - Parkinson Disease/physiopathology/*rehabilitation
MH  - Photic Stimulation/*methods
MH  - Postural Balance
MH  - Research Design
MH  - Standing Position
MH  - Time and Motion Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Gait
OT  - Posture
OT  - Quality of life
OT  - Rehabilitation
EDAT- 2018/06/11 06:00
MHDA- 2019/07/16 06:00
CRDT- 2018/06/11 06:00
PHST- 2017/12/25 00:00 [received]
PHST- 2018/04/30 00:00 [revised]
PHST- 2018/05/02 00:00 [accepted]
PHST- 2018/06/11 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2018/06/11 06:00 [entrez]
AID - S0003-9993(18)30353-8 [pii]
AID - 10.1016/j.apmr.2018.05.007 [doi]
PST - ppublish
SO  - Arch Phys Med Rehabil. 2018 Dec;99(12):2478-2484.e1. doi: 
      10.1016/j.apmr.2018.05.007. Epub 2018 Jun 7.