PMID- 29886452
OWN - NLM
STAT- MEDLINE
DCOM- 20181012
LR  - 20220408
IS  - 1868-503X (Electronic)
IS  - 1868-5021 (Linking)
VI  - 9
IP  - 1
DP  - 2018 Jun 9
TI  - Polymorphisms in DNA repair genes increase the risk for type 2 diabetes mellitus 
      and hypertension.
PG  - 80-93
LID - /j/bmc.2018.9.issue-1/bmc-2018-0008/bmc-2018-0008.xml [pii]
LID - 10.1515/bmc-2018-0008 [doi]
AB  - We investigated the effect of polymorphisms in four DNA repair genes, viz. RAD18 
      Arg302Gln (G>A) (rs373572), XPD Asp312Asn (G>A) (rs1799793), APE1 Asp148Glu (T>G) 
      (rs3136820), and OGG1 Ser326Cys (C>G) (rs1052133) on the risk for type 2 diabetes 
      mellitus (T2DM) and hypertension (HT) in association with smoking, tobacco 
      chewing, and alcohol consumption in a population from Northeast India. The study 
      subjects were comprised of 70 patients suffering from both T2DM and HT and 83 
      healthy controls. Genotyping was performed using ARMS-PCR for XPD Asp312Asn (G>A) 
      and PCR-CTPP for RAD18 Arg302Gln (G>A), APE1 Asp148Glu (T>G) and OGG1 Ser326Cys 
      (C>G). The RAD18 Gln/Gln genotype was found to significantly increase the risk 
      for T2DM and HT by 30 fold. Significant high risk was observed for individuals 
      with XPD Asn/Asn-RAD18 Arg/Gln genotypes. Smoking was found to be the single most 
      important independent risk factor for T2DM and HT. This study concludes that 
      RAD18 Arg302Gln and XPD Asp312Asn polymorphisms might increase the risk for T2DM 
      and HT in association with smoking, tobacco chewing, and/or alcohol consumption, 
      while APE1 Asp148Glu (T>G) and OGG1 Ser326Cys (C>G) polymorphisms do not 
      contribute to such risk.
FAU - Das, Sambuddha
AU  - Das S
AD  - Department of Biotechnology, Assam University, Silchar-788011, Assam, India.
FAU - Purkayastha, Sukanya
AU  - Purkayastha S
AD  - Department of Biotechnology, Assam University, Silchar-788011, Assam, India.
FAU - Roy, Hirakjyoti
AU  - Roy H
AD  - Department of Biotechnology, Assam University, Silchar-788011, Assam, India.
FAU - Sinha, Anima
AU  - Sinha A
AD  - Department of Biotechnology, Assam University, Silchar-788011, Assam, India.
FAU - Choudhury, Yashmin
AU  - Choudhury Y
AD  - Department of Biotechnology, Assam University, Silchar-788011, Assam, India.
LA  - eng
PT  - Journal Article
DEP - 20180609
PL  - Germany
TA  - Biomol Concepts
JT  - Biomolecular concepts
JID - 101518829
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RAD18 protein, human)
RN  - 0 (Reactive Oxygen Species)
RN  - 9007-49-2 (DNA)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 3.2.2.- (DNA Glycosylases)
RN  - EC 3.2.2.- (oxoguanine glycosylase 1, human)
RN  - EC 3.6.4.12 (Xeroderma Pigmentosum Group D Protein)
RN  - EC 4.2.99.18 (APEX1 protein, human)
RN  - EC 4.2.99.18 (DNA-(Apurinic or Apyrimidinic Site) Lyase)
RN  - EC 5.99.- (ERCC2 protein, human)
SB  - IM
MH  - Alcohol Drinking
MH  - Case-Control Studies
MH  - DNA/analysis/isolation & purification
MH  - DNA Glycosylases/genetics
MH  - DNA Repair
MH  - DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics
MH  - DNA-Binding Proteins/genetics
MH  - Diabetes Mellitus, Type 2/enzymology/*genetics
MH  - Female
MH  - Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Hypertension/enzymology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Reactive Oxygen Species
MH  - Smoking
MH  - Ubiquitin-Protein Ligases/genetics
MH  - Xeroderma Pigmentosum Group D Protein/genetics
OTO - NOTNLM
OT  - APE1
OT  - HT
OT  - OGG1
OT  - RAD18
OT  - T2DM
OT  - XPD
EDAT- 2018/06/11 06:00
MHDA- 2018/10/13 06:00
CRDT- 2018/06/11 06:00
PHST- 2018/02/22 00:00 [received]
PHST- 2018/04/09 00:00 [accepted]
PHST- 2018/06/11 06:00 [entrez]
PHST- 2018/06/11 06:00 [pubmed]
PHST- 2018/10/13 06:00 [medline]
AID - /j/bmc.2018.9.issue-1/bmc-2018-0008/bmc-2018-0008.xml [pii]
AID - 10.1515/bmc-2018-0008 [doi]
PST - epublish
SO  - Biomol Concepts. 2018 Jun 9;9(1):80-93. doi: 10.1515/bmc-2018-0008.