PMID- 29886565
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20181114
IS  - 1534-312X (Electronic)
IS  - 1522-8037 (Linking)
VI  - 20
IP  - 7
DP  - 2018 Jun 9
TI  - The Proton Pump Inhibitor Nonresponder: a Behavioral Approach to Improvement and 
      Wellness.
PG  - 34
LID - 10.1007/s11894-018-0641-x [doi]
AB  - PURPOSE OF REVIEW: Gastroesophageal reflux disease (GERD) is a difficult to treat 
      medical condition, where nearly 40% of patients are refractory to standard 
      medical intervention, which typically begins with a proton pump inhibitor (PPI). 
      These PPI nonresponders represent a population of patients, where treatment 
      planning must be individualized; multidisciplinary and psychiatric comorbidities 
      should be considered. This review highlights treatment options that include 
      neuromodulators, lifestyle, and psychological interventions for the PPI 
      nonresponder. RECENT FINDINGS: Mental health specialists in the field of 
      psychogastroenterology can aid in the management of esophageal hypersensitivity, 
      which can drive the symptom experience of a PPI nonresponder. Considerations for 
      comorbid anxiety and depression in this population require careful assessment and 
      treatment. Physicians are encouraged to create realistic expectations for symptom 
      management and offer multidisciplinary options for treatment early in care. 
      Patients will frequently benefit from working with a GI psychologist and find 
      value in behavioral interventions.
FAU - Riehl, Megan E
AU  - Riehl ME
AD  - University of Michigan, Division of Gastroenterology, 3912 Taubman Center 1500 E. 
      Medical Center Drive, Ann Arbor, MI, 48109, USA. mriehl@med.umich.edu.
FAU - Chen, Joan W
AU  - Chen JW
AD  - University of Michigan, Division of Gastroenterology, 3912 Taubman Center 1500 E. 
      Medical Center Drive, Ann Arbor, MI, 48109, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180609
PL  - United States
TA  - Curr Gastroenterol Rep
JT  - Current gastroenterology reports
JID - 100888896
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Behavior Therapy
MH  - Gastroesophageal Reflux/drug therapy/*psychology/*therapy
MH  - Health Behavior
MH  - Humans
MH  - Hypnosis
MH  - Life Style
MH  - Neurotransmitter Agents/therapeutic use
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Stress, Psychological/therapy
MH  - Treatment Failure
OTO - NOTNLM
OT  - Cognitive behavioral therapy
OT  - Esophageal hypersensitivity
OT  - Gastroesophageal reflux disease
OT  - Hypnosis
OT  - PPI nonresponder
OT  - Psychogastroenterology
EDAT- 2018/06/11 06:00
MHDA- 2018/10/12 06:00
CRDT- 2018/06/11 06:00
PHST- 2018/06/11 06:00 [entrez]
PHST- 2018/06/11 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
AID - 10.1007/s11894-018-0641-x [pii]
AID - 10.1007/s11894-018-0641-x [doi]
PST - epublish
SO  - Curr Gastroenterol Rep. 2018 Jun 9;20(7):34. doi: 10.1007/s11894-018-0641-x.