PMID- 29886757
OWN - NLM
STAT- MEDLINE
DCOM- 20190226
LR  - 20190226
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 60
IP  - 2
DP  - 2019 Feb
TI  - An open label, prospective, multicenter, non-interventional study of iodixanol 
      270 mg I/mL for use in individuals undergoing computed tomography angiography in 
      real-world clinical practice.
PG  - 177-185
LID - 10.1177/0284185118774917 [doi]
AB  - BACKGROUND: Concern about radiation exposure is leading to an increasing interest 
      in low-concentration contrast medium administration. PURPOSE: To evaluate the 
      image quality and safety profile after administration of iodixanol 270 mg I/mL at 
      100-kVp tube voltage with iterative reconstruction in subjects undergoing 
      computed tomography angiography (CTA). MATERIAL AND METHODS: Patients who 
      completed CTA examination using iodixanol 270 mg I/mL and 100-kVp tube voltage 
      along with iterative reconstruction for coronary, aortic, head and neck, renal, 
      or pulmonary arteries were included. Image quality was qualitatively and 
      quantitatively evaluated. Incidence of adverse events (AEs) and adverse drug 
      reactions (ADRs) within seven days and radiation dose were also analyzed. 
      RESULTS: A total of 4513 individuals in 42 centers in China were enrolled, among 
      which 4367 were included in efficacy analysis. The mean image quality score was 
      4.8 +/- 0.45 across all arteries (all above 4.6) and 99.7% of the individuals' 
      images were classified as evaluable. The CT attenuation, signal-to-noise ratio 
      (SNR), and contrast-to-noise ratio (CNR) in the regions of interest (ROIs) were 
      431.79 +/- 99.018, 18.29 +/- 11.947, and 28.21 +/- 19.535 HU, respectively. Of all the 
      participants, 68 (1.5%) and 65 (1.4%) experienced AEs and ADRs, respectively. No 
      serious AEs or AEs leading to discontinuation occurred. The average effective 
      radiation dose was 3.13 +/- 2.550 mSv. CONCLUSION: Iodixanol 270 mg I/mL in 
      combination with 100-kVp tube voltage and iterative reconstruction could be 
      safely applied in CTA and yield high-quality and evaluable images with reduced 
      radiation dose.
FAU - Du, Xiangying
AU  - Du X
AD  - 1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 
      PR China.
FAU - Lu, Bin
AU  - Lu B
AD  - 2 Department of Radiology, Fuwai Hospital, National Center for Cardiovascular 
      Disease, Chinese Academy of Medical Science, Peking Union Medical College, 
      Beijing, PR China.
FAU - Hu, Daoyu
AU  - Hu D
AD  - 3 Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, PR China.
FAU - Song, Bin
AU  - Song B
AD  - 4 Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, PR China.
FAU - Li, Kuncheng
AU  - Li K
AUID- ORCID: 0000-0001-9841-0646
AD  - 1 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 
      PR China.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20180609
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
RN  - 0 (Contrast Media)
RN  - 0 (Triiodobenzoic Acids)
RN  - HW8W27HTXX (iodixanol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - China/epidemiology
MH  - Computed Tomography Angiography/*methods
MH  - Contrast Media/*administration & dosage/adverse effects
MH  - Drug Hypersensitivity/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Triiodobenzoic Acids/*administration & dosage/adverse effects
OTO - NOTNLM
OT  - Computed tomography angiography
OT  - image quality
OT  - iodixanol
OT  - radiation dose
EDAT- 2018/06/12 06:00
MHDA- 2019/02/27 06:00
CRDT- 2018/06/12 06:00
PHST- 2018/06/12 06:00 [pubmed]
PHST- 2019/02/27 06:00 [medline]
PHST- 2018/06/12 06:00 [entrez]
AID - 10.1177/0284185118774917 [doi]
PST - ppublish
SO  - Acta Radiol. 2019 Feb;60(2):177-185. doi: 10.1177/0284185118774917. Epub 2018 Jun 
      9.