PMID- 29887831
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 9
DP  - 2018
TI  - Metformin Use Is Not Associated With B(12) Deficiency or Neuropathy in Patients 
      With Type 2 Diabetes Mellitus in Qatar.
PG  - 248
LID - 10.3389/fendo.2018.00248 [doi]
LID - 248
AB  - BACKGROUND: Metformin may lead to B(12) deficiency and neuropathy. There are no 
      published data on the prevalence of Metformin-related B(12) deficiency and 
      neuropathy in the Arabian Gulf. AIMS: Determine whether Metformin intake is 
      associated with B(12) deficiency and whether B(12) deficiency is associated with 
      diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy. METHODS: 
      Patients with type 2 diabetes mellitus (T2DM) (n = 362) attending outpatient 
      clinics at HMC underwent assessment of B(12) levels, the DN4 questionnaire, and 
      vibration perception threshold (VPT). RESULTS: Comparing Metformin to 
      non-Metformin users there were no differences in B(12) levels, VPT, or DN4. The 
      prevalence of B(12) deficiency (B(12) <133 pmol/l) was lower (P < 0.01) in 
      Metformin (8%) compared to non-Metformin (19%) users. Patients with B(12) 
      deficiency had a comparable prevalence and severity of sensory neuropathy and 
      painful neuropathy to patients without B(12) deficiency. CONCLUSION: Serum B(12) 
      levels were comparable between Metformin and non-Metformin users with T2DM in 
      Qatar. T2DM patients on Metformin had a lower prevalence of B(12) deficiency. 
      Furthermore, the prevalence and severity of neuropathy and painful diabetic 
      neuropathy were comparable between patients with and without B(12) deficiency.
FAU - Elhadd, Tarik
AU  - Elhadd T
AD  - National Diabetes & Endocrine Centre, Al-Wakra Hospital, Hamad Medical 
      Corporation, Doha, Qatar.
AD  - National Diabetes & Endocrine Centre, Hamad General Hospital, Hamad Medical 
      Corporation, Doha, Qatar.
FAU - Ponirakis, Georgios
AU  - Ponirakis G
AD  - Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
FAU - Dabbous, Zeinab
AU  - Dabbous Z
AD  - National Diabetes & Endocrine Centre, Hamad General Hospital, Hamad Medical 
      Corporation, Doha, Qatar.
FAU - Siddique, Mashhood
AU  - Siddique M
AD  - National Diabetes & Endocrine Centre, Hamad General Hospital, Hamad Medical 
      Corporation, Doha, Qatar.
FAU - Chinnaiyan, Subitha
AU  - Chinnaiyan S
AD  - National Diabetes & Endocrine Centre, Hamad General Hospital, Hamad Medical 
      Corporation, Doha, Qatar.
FAU - Malik, Rayaz A
AU  - Malik RA
AD  - National Diabetes & Endocrine Centre, Hamad General Hospital, Hamad Medical 
      Corporation, Doha, Qatar.
AD  - Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
LA  - eng
PT  - Journal Article
DEP - 20180525
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC5980977
OTO - NOTNLM
OT  - diabetic neuropathy
OT  - diabetic painful neuropathy
OT  - metformin
OT  - type 2 diabetes mellitus
OT  - vitamin B12 deficiency
EDAT- 2018/06/12 06:00
MHDA- 2018/06/12 06:01
PMCR- 2018/01/01
CRDT- 2018/06/12 06:00
PHST- 2018/02/03 00:00 [received]
PHST- 2018/05/02 00:00 [accepted]
PHST- 2018/06/12 06:00 [entrez]
PHST- 2018/06/12 06:00 [pubmed]
PHST- 2018/06/12 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2018.00248 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2018 May 25;9:248. doi: 10.3389/fendo.2018.00248. 
      eCollection 2018.