PMID- 29888569
OWN - NLM
STAT- MEDLINE
DCOM- 20190405
LR  - 20190405
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 43
IP  - 5
DP  - 2018 May 25
TI  - [ASL-based Observation of Central Nervous System Responses to Acupuncture 
      Analgesia for People with Different Sensitivities].
PG  - 319-25
LID - 10.13702/j.1000-0607.170196 [doi]
AB  - OBJECTIVE: To examine the effects of different sensitivities on the effectiveness 
      of acupuncture analgesia by observing activation change characteristics of 
      cerebral areas resulting from the influences of constitutions on analgesia 
      effects and to discuss the response mechanism of central nervous system (CNS) to 
      determine the factor of constitutions on acupuncture efficacy using cerebral 
      functional magnetic resonance imaging arterial spin labeling (fMRI-ASL). METHODS: 
      Participants with different sensitivities were assessed according to standard 
      screening and grouped into two groups: insensitivity group (n＝24) and sensitivity 
      group (n＝22). All participants were given acupuncture at the left-sided Zusanli 
      point. Pressure pain threshold (PPT) of their body surface was determined before 
      and after the acupuncture, and the two groups were subsequently compared in terms 
      of analgesic effects and PPT rate of change; cerebral fMRI-ASL was performed; 
      software such as SPM 8 and ASLtbx were utilized to preprocess the results, and 
      correlation between regional cerebral blood flow (rCBF) and visual analog scale 
      (VAS) score was determined using Pearson's correlational analysis. RESULTS: VAS 
      score in the sensitivity group was significantly higher than that in the 
      insensitivity group (P< 0.05); after acupuncture, PPT rate of change in the 
      sensitivity group was higher than that in the insensitivity group (P< 0.05). The 
      analyses revealed that there was a negative correlation between rCBF and VAS 
      score for the right-sided anterior cingulate cortex in the insensitivity group 
      and superior frontal gyrus in the sensitivity group (|r|>0.3 and P<0.05). 
      CONCLUSION: Different sensitivity to acupuncture is one of the crucial factors 
      influencing analgesia effects. The sensitivity group had superior analgesia 
      effect than the insensitivity group. Acupuncture might deactivate cerebral 
      functional areas to generate analgesic effects.The superior frontal gyrus and 
      bilateral anterior cingulate cortex, because of deactivation, play a positive 
      role in sensitive patients, which is probably one of the CNS cerebral areas 
      responding to acupuncture analgesia of people who are sensitive to acupuncture.
FAU - Ma, Lin
AU  - Ma L
AD  - Department of Traditional Chinese Medicine of Chongqing Medical University, 
      Chongqing 400016, China; Key Laboratory of Metabolic Disease Prevention and 
      Treatment by Traditional Chinese Medicine, Chongqing 400016, China.
FAU - Li, Xue-Zhi
AU  - Li XZ
AD  - Department of Traditional Chinese Medicine of Chongqing Medical University, , 
      Chongqing 400016, China; Key Laboratory of Metabolic Disease Prevention and 
      Treatment by Traditional Chinese Medicine, Chongqing 400016, China.
FAU - Fu, Ni-Ni
AU  - Fu NN
AD  - Department of Traditional Chinese Medicine of Chongqing Medical University, 
      Chongqing 400016, China.
FAU - Yang, Xiao-Guang
AU  - Yang XG
AD  - Department of Rehabilitation, Xiangyang Central Hospital, Xiangyang 441000, Hubei 
      Province.
FAU - Xi, Xiao-Fang
AU  - Xi XF
AD  - Department of Traditional Chinese Medicine of Chongqing Medical University, 
      Chongqing 400016, China.
FAU - Liu, Fei
AU  - Liu F
AD  - Department of Traditional Chinese Medicine of Chongqing Medical University, 
      Chongqing 400016, China.
FAU - Ren, Yi
AU  - Ren Y
AD  - Department of Rehabilitation, Hanzhong Central Hospital, Hanzhong 723000, Shaanxi 
      Province.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
SB  - IM
MH  - *Acupuncture Analgesia
MH  - Brain
MH  - Humans
MH  - Magnetic Resonance Angiography
OTO - NOTNLM
OT  - Acupuncture analgesia
OT  - Arterial spin labeling technology
OT  - Cerebral functional magnetic resonance imaging
OT  - Constitution
EDAT- 2018/06/12 06:00
MHDA- 2019/04/06 06:00
CRDT- 2018/06/12 06:00
PHST- 2018/06/12 06:00 [entrez]
PHST- 2018/06/12 06:00 [pubmed]
PHST- 2019/04/06 06:00 [medline]
AID - 10.13702/j.1000-0607.170196 [doi]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2018 May 25;43(5):319-25. doi: 10.13702/j.1000-0607.170196.