PMID- 29890386
OWN - NLM
STAT- MEDLINE
DCOM- 20190501
LR  - 20190501
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 119
DP  - 2018 Aug
TI  - Effects of Isatis root polysaccharide in mice infected with H3N2 swine influenza 
      virus.
PG  - 91-98
LID - S0034-5288(17)30646-X [pii]
LID - 10.1016/j.rvsc.2018.04.012 [doi]
AB  - Isatis root polysaccharide (IRPS) has gained attention in the field of virology. 
      However, very few studies have evaluated the effects of IRPS on H3N2 swine 
      influenza virus (SIV). The antiviral activities of IRPS against SIV were 
      investigated in vitro through three different modes and in vivo in an 
      experimental mouse model of SIV infection. Mice were treated by oral gavage with 
      various doses of IRPS before being experimentally infected with SIV 
      A/swine/Henan/2010(H3N2). The antiviral effects of IRPS were evaluated by 
      clinical signs, weight, histopathology, cytokine levels in lung homogenates and 
      serum nitric oxide (NO) and IgG levels at 2, 5 and 9 d post-infection. IRPS 
      demonstrated an inhibitory effect on SIV in Madin-Darby canine kidney cells. 
      Additionally, IRPS significantly improved symptoms, reduced pathological changes 
      and enhanced serum levels of NO and IgG in SIV-infected mice. Furthermore, 
      detection of cytokines in lung homogenates showed IRPS could alter cytokine 
      production to improve immune responses and systemic ability to repair 
      inflammation. Moreover, IRPS extenuated the pulmonary inflammatory response. The 
      results show that various concentrations of IRPS exert antiviral effects in vitro 
      and in vivo. In an experimental mouse model of SIV infection, IRPS at a dose of 
      75 mg/kg was effective.
CI  - Copyright (c) 2018. Published by Elsevier Ltd.
FAU - Wang, Xuebing
AU  - Wang X
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450000, China; Key Laboratory for Animal-Derived Food Safety of Henan 
      province, Zhengzhou 450000, China.
FAU - Xue, Yang
AU  - Xue Y
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450000, China.
FAU - Li, Yongliang
AU  - Li Y
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450000, China.
FAU - Liu, Fang
AU  - Liu F
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450000, China; Key Laboratory for Animal-Derived Food Safety of Henan 
      province, Zhengzhou 450000, China.
FAU - Yan, Yanhua
AU  - Yan Y
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450000, China.
FAU - Zhang, Hongying
AU  - Zhang H
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450000, China; Key Laboratory for Animal-Derived Food Safety of Henan 
      province, Zhengzhou 450000, China. Electronic address: hongyingnd@163.com.
FAU - Jin, Qianyue
AU  - Jin Q
AD  - Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of 
      Agricultural Sciences, Zhengzhou 450002, China.
LA  - eng
PT  - Journal Article
DEP - 20180501
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Antiviral Agents)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*pharmacology
MH  - Dogs
MH  - Influenza A Virus, H1N1 Subtype
MH  - *Influenza A Virus, H3N2 Subtype
MH  - Isatis/*chemistry
MH  - Mice
MH  - Orthomyxoviridae Infections/drug therapy/*veterinary
MH  - Polysaccharides/*pharmacology
MH  - Swine
MH  - Swine Diseases/drug therapy
OTO - NOTNLM
OT  - Isatis root polysaccharide
OT  - Mice
OT  - Swine influenza virus
EDAT- 2018/06/12 06:00
MHDA- 2019/05/02 06:00
CRDT- 2018/06/12 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2018/04/16 00:00 [revised]
PHST- 2018/04/30 00:00 [accepted]
PHST- 2018/06/12 06:00 [pubmed]
PHST- 2019/05/02 06:00 [medline]
PHST- 2018/06/12 06:00 [entrez]
AID - S0034-5288(17)30646-X [pii]
AID - 10.1016/j.rvsc.2018.04.012 [doi]
PST - ppublish
SO  - Res Vet Sci. 2018 Aug;119:91-98. doi: 10.1016/j.rvsc.2018.04.012. Epub 2018 May 
      1.