PMID- 29890469
OWN - NLM
STAT- MEDLINE
DCOM- 20181115
LR  - 20181115
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 105
DP  - 2018 Sep
TI  - Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits 
      anti-inflammatory activity in lipopolysaccharide/interferon gamma-activated murine 
      macrophages and animal models of inflammation.
PG  - 606-615
LID - S0753-3322(18)31607-X [pii]
LID - 10.1016/j.biopha.2018.06.019 [doi]
AB  - Solanine A is a novel steroidal alkaloid isolated from Solanum nigrum Linn., a 
      medicinal and edible plant which is widely used for treating various inflammatory 
      diseases. In this study, we found that solanine A markedly suppressed the 
      production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in 
      lipopolysaccharide/interferon-gamma (LPS/IFNgamma)-stimulated RAW264.7 cells, and 
      attenuated xylene, carrageenan and agar-induced inflammation in mice. The mRNA 
      levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), tumor 
      necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and -1beta (IL-1beta), as well as 
      C-X-C motif chemokine ligand-9 (CXCL9), were significantly decreased by solanine 
      A. Furthermore, solanine A also suppressed LPS/IFNgamma-induced protein expression of 
      iNOS and COX2. Mechanistically, solanine A inhibited the nuclear translocation of 
      nuclear factor-kappaB (NF-kappaB) through the prevention of NF-kappaB p65 and inhibitory kappaB-alpha 
      (IkappaBalpha) phosphorylation and IkappaBalpha degradation, and it also suppressed activation of 
      extracellular regulated protein kinases (ERK), signal transducers and activators 
      of transcription-1 (STAT1) and serine/threonine protein kinase Akt in 
      LPS/IFNgamma-stimulated RAW264.7 macrophages and agar-induced granuloma model in 
      mice. Taken together, solanine A exhibits a potent anti-inflammatory activity in 
      LPS/IFNgamma- activated macrophages and animal models of inflammation through 
      inhibition of NF-kappaB, ERK1/2, Akt and STAT1 signaling pathways, suggesting that 
      solanine A may be a valuable leading compound in the treatment of inflammatory 
      diseases.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Zhao, Lin
AU  - Zhao L
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Ministry of Education), West China Second University Hospital, Sichuan 
      University, Chengdu, China.
FAU - Wang, Lun
AU  - Wang L
AD  - Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
FAU - Di, Suo-Ni
AU  - Di SN
AD  - Institute of Traditional Chinese Medicine, The 451st Hospital of People's 
      Liberation Army, Xi'an, China.
FAU - Xu, Qian
AU  - Xu Q
AD  - Department of Pathophysiology, West China College of Basic and Forensic Medicine, 
      Sichuan University, Chengdu, China.
FAU - Ren, Qing-Cuo
AU  - Ren QC
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Ministry of Education), West China Second University Hospital, Sichuan 
      University, Chengdu, China.
FAU - Chen, Shan-Ze
AU  - Chen SZ
AD  - Department of Pathophysiology, West China College of Basic and Forensic Medicine, 
      Sichuan University, Chengdu, China.
FAU - Huang, Ning
AU  - Huang N
AD  - Department of Pathophysiology, West China College of Basic and Forensic Medicine, 
      Sichuan University, Chengdu, China.
FAU - Jia, Da
AU  - Jia D
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Ministry of Education), West China Second University Hospital, Sichuan 
      University, Chengdu, China.
FAU - Shen, Xiao-Fei
AU  - Shen XF
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Ministry of Education), West China Second University Hospital, Sichuan 
      University, Chengdu, China. Electronic address: szx379@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180608
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Solanaceous Alkaloids)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/isolation & purification/*pharmacology/therapeutic use
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Disease Models, Animal
MH  - Edema/*drug therapy/immunology
MH  - Granuloma/*drug therapy/immunology
MH  - Interferon-gamma/pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophage Activation/*drug effects/immunology
MH  - Macrophages/*drug effects/immunology
MH  - Male
MH  - Mice, Inbred ICR
MH  - Solanaceous Alkaloids/isolation & purification/*pharmacology/therapeutic use
MH  - Solanum nigrum/*chemistry
OTO - NOTNLM
OT  - Anti-inflammatory activity
OT  - NF-kappaB and MAPKs cascades
OT  - PI3K/Akt and JAK/STATs signalings
OT  - Solanine A
OT  - Solanum nigrum Linn.
EDAT- 2018/06/12 06:00
MHDA- 2018/11/16 06:00
CRDT- 2018/06/12 06:00
PHST- 2018/03/10 00:00 [received]
PHST- 2018/06/03 00:00 [revised]
PHST- 2018/06/04 00:00 [accepted]
PHST- 2018/06/12 06:00 [pubmed]
PHST- 2018/11/16 06:00 [medline]
PHST- 2018/06/12 06:00 [entrez]
AID - S0753-3322(18)31607-X [pii]
AID - 10.1016/j.biopha.2018.06.019 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Sep;105:606-615. doi: 10.1016/j.biopha.2018.06.019. 
      Epub 2018 Jun 8.