PMID- 29890598
OWN - NLM
STAT- MEDLINE
DCOM- 20180621
LR  - 20180621
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 622-623
DP  - 2018 May 1
TI  - Increased levels of persistent organic pollutants in serum one year after a great 
      weight loss in humans: Are the levels exceeding health based guideline values?
PG  - 1317-1326
LID - S0048-9697(17)33299-0 [pii]
LID - 10.1016/j.scitotenv.2017.11.241 [doi]
AB  - BACKGROUND: With the growing prevalence of obesity, an increased number of 
      bariatric surgeries are being performed. Lipophilic persistent organic pollutants 
      (POPs) are stored in adipose tissue, and an increased release of lipophilic POPs 
      into the blood circulation may occur following rapid weight loss such as after 
      bariatric surgery. OBJECTIVES: To evaluate and compare POP levels in serum before 
      and after bariatric surgery, and to assess if the POP levels exceeded health 
      based guideline values, with particular focus on women of childbearing age 
      (WCBA). METHODS: Serum samples from 63 patients before and one year after 
      bariatric surgery were analysed for organochlorine pesticides (OCPs); 
      polychlorinated biphenyls (PCBs); and brominated flame retardants (BFRs). 
      RESULTS: Mean weight loss one year after surgery was 32.1kg. The levels of all 
      the analysed POPs in serum increased during the study period. Median levels of 
      dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzen (HCB) and PCB-153 
      increased from 90.2ng/g lipid weight (lw) to 158.5ng/glw, from 21.1ng/glw to 
      36.4ng/glw and from 48.7ng/glw to 71.5ng/glw, respectively. The highest 
      percentage increase was observed for PCB -138, with 83.1%. BFRs were detected in 
      low sample numbers and at low levels. Guideline values for SigmaPCB(6) in serum were 
      exceeded for 5% of the participants. CONCLUSIONS: Weight loss after bariatric 
      surgery resulted in increases of POPs levels in serum between 46.7%-83.1%. 
      Guideline values for SigmaPCB(6) in serum were exceeded for 5% of the participants. 
      For WCBA, the possible transfer of comparable levels to infants warrants further 
      attention.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Jansen, Aina
AU  - Jansen A
AD  - Center for Morbid Obesity, Department of Surgery, Innlandet Hospital Trust, Kyrre 
      Grepps Gate 11, N-2819 Gjovik, Norway; Department of Food Safety and Infection 
      Biology, Norwegian University of Life Sciences (NMBU), Campus Adamstuen, P.O. Box 
      8146 Dep, N-0033 Oslo, Norway. Electronic address: 
      aina.jansen@sykehuset-innlandet.no.
FAU - Polder, Anuschka
AU  - Polder A
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences (NMBU), Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway.
FAU - Muller, Mette H B
AU  - Muller MHB
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences (NMBU), Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway.
FAU - Skjerve, Eystein
AU  - Skjerve E
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences (NMBU), Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway.
FAU - Aaseth, Jan
AU  - Aaseth J
AD  - Innlandet Hospital Trust, Kongsvinger Hospital Division, Parkveien 35, N-2212 
      Kongsvinger, Norway; Faculty of Public Health, Inland Norway University of 
      Applied Sciences, PO Box 400, N-2418 Elverum, Norway.
FAU - Lyche, Jan L
AU  - Lyche JL
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences (NMBU), Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway.
LA  - eng
PT  - Journal Article
DEP - 20171213
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 7Y6JIG1867 (2,2',3',4,4',5-hexachlorobiphenyl)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Bariatric Surgery/adverse effects
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Environmental Exposure/*analysis/statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Flame Retardants/metabolism
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Organic Chemicals/*blood
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Weight Loss/*physiology
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Breast milk
OT  - Estimated daily intake
OT  - Increased blood levels of POPs
OT  - Obesity
OT  - Persistent organic pollutants (POPs)
EDAT- 2018/06/13 06:00
MHDA- 2018/06/22 06:00
CRDT- 2018/06/13 06:00
PHST- 2017/07/12 00:00 [received]
PHST- 2017/10/27 00:00 [revised]
PHST- 2017/11/20 00:00 [accepted]
PHST- 2018/06/13 06:00 [entrez]
PHST- 2018/06/13 06:00 [pubmed]
PHST- 2018/06/22 06:00 [medline]
AID - S0048-9697(17)33299-0 [pii]
AID - 10.1016/j.scitotenv.2017.11.241 [doi]
PST - ppublish
SO  - Sci Total Environ. 2018 May 1;622-623:1317-1326. doi: 
      10.1016/j.scitotenv.2017.11.241. Epub 2017 Dec 13.