PMID- 29891462
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20231014
IS  - 1673-4254 (Print)
IS  - 2663-0842 (Electronic)
IS  - 1673-4254 (Linking)
VI  - 38
IP  - 5
DP  - 2018 May 20
TI  - [Association of plasma level of advanced oxidation protein products with 
      Framingham risk score in type 2 diabetic patients without vascular diseases].
PG  - 620-624
AB  - OBJECTIVE: To explore the association of plasma level of advanced oxidation 
      protein products (AOPPs) with Framingham risk score in type 2 diabetic patients 
      without vascular diseases. METHDOS: This cross-sectional study was conducted 
      among type 2 diabetic patients without vascular diseases recruited from 3 
      affiliated hospitals of Southern Medical University between March, 2010 and May, 
      2011, with age- and gender-matched healthy individuals as the control group. The 
      demographic data were collected from all the participants, and the biochemical 
      indexes and plasma levels of AOPPs were examined. The risk of cardiovascular 
      disease in 10 years was assessed for all the participants based on their 
      Framingham risk scores. RESULTS: A total of 112 diabetic patients and 49 healthy 
      subjects were enrolled in this study. The diabetic patients had significantly 
      higher body mass index (BMI), blood glucose, triglyceride, low-density 
      lipoprotein (LDL), plasma AOPPs and Framingham risk score but lower high-density 
      lipoprotein level than the control subjects. Spearman correlation analysis showed 
      that plasma level of AOPPs was positively correlated with the Framingham risk 
      score (r=-0.44, P<0.001), and further multiple linear regression analysis 
      suggested that plasma AOPPs level was independently correlated with the 
      Framingham risk score (beta0.305, P<0.001). CONCLUSION: Type 2 diabetic patients 
      without vascular diseases have significantly higher plasma levels of AOPPs and 
      are at a greater risk of cardiovascular events in 10 years than healthy 
      individuals. Plasma AOPPs are positively correlated with the Framingham risk 
      score, suggesting the value of plasma AOPPs level in predicting the risk of 
      cardiovascular events in these patients.
FAU - Xie, Chao
AU  - Xie C
AD  - Department of Nephrology, Foshan First People's Hospital, Foshan 528000, 
      China.E-mail: xie123456jiang@126.com.
FAU - Tian, Jie
AU  - Tian J
FAU - Li, Wei
AU  - Li W
FAU - Liang, Min
AU  - Liang M
FAU - Kong, Yao-Zhong
AU  - Kong YZ
LA  - chi
PT  - Journal Article
PT  - Multicenter Study
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Advanced Oxidation Protein Products)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Advanced Oxidation Protein Products/*blood
MH  - Biomarkers/blood
MH  - Cardiovascular Diseases/etiology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Humans
MH  - Longitudinal Studies
MH  - Oxidative Stress
MH  - Risk Factors
PMC - PMC6743899
EDAT- 2018/06/13 06:00
MHDA- 2019/02/05 06:00
PMCR- 2018/05/20
CRDT- 2018/06/13 06:00
PHST- 2018/06/13 06:00 [entrez]
PHST- 2018/06/13 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
PHST- 2018/05/20 00:00 [pmc-release]
AID - nfykdxxb-38-5-620 [pii]
AID - 10.3969/j.issn.1673-4254.2018.05.19 [doi]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2018 May 20;38(5):620-624. doi: 
      10.3969/j.issn.1673-4254.2018.05.19.