PMID- 29892576
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2255-4971 (Print)
IS  - 2255-4971 (Electronic)
IS  - 2255-4971 (Linking)
VI  - 53
IP  - 3
DP  - 2018 May-Jun
TI  - Neurotrophin expression and histomorphometric evaluation in Wistar rats subjected 
      to neural mobilization after compression of the median nerve.
PG  - 276-280
LID - 10.1016/j.rboe.2018.03.006 [doi]
AB  - OBJECTIVE: To evaluate the neurotrophin mRNA expression and axon count in the 
      median nerve of Wistar rats submitted to neural mobilization (NM) after nerve 
      compression. METHODS: Eighteen animals were randomly divided into G1 (nerve 
      compression only), G2 (NM for 1 min), and G3 (NM for 3 min). For NM, the animals 
      were anesthetized and the right scapula received the mobilization, adapted as 
      indicated for humans, on alternate days, from the third to the 13th postoperative 
      (PO) day, totaling six days of therapy. On the 14th PO day, animals were 
      anesthetized and euthanized. Fragments of the median nerve, distal to the 
      compression procedure, were removed for histomorphometric analysis and expression 
      of neurotrophins, nerve growth factor (NGF), and brain-derived neurotrophic 
      factor (BDNF) by RT-PCR. RESULTS: Histomorphometric analysis revealed differences 
      in the number of axons in the injured side, which was significantly lower in the 
      injured limb nerve compared to the control limb, whereas the RT-PCR analysis 
      showed no significant differences in the expression of NGF or BDNF. CONCLUSION: 
      NM treatment did not affect median nerve regeneration, which maintained normal 
      recovery rates.
FAU - Marcioli, Marieli Araujo Rossoni
AU  - Marcioli MAR
AD  - Universidade Estadual do Oeste do Parana (Unioeste), Cascavel, PR, Brazil.
FAU - Silva, Jose Luis da Conceicao
AU  - Silva JLDC
AD  - Programa de Ciencias Farmaceuticas, Universidade Estadual do Oeste do Parana 
      (Unioeste), Cascavel, PR, Brazil.
FAU - Ribeiro, Lucineia de Fatima Chasko
AU  - Ribeiro LFC
AD  - Programa de Biociencias e Saude, Universidade Estadual do Oeste do Parana 
      (Unioeste), Cascavel, PR, Brazil.
FAU - Brancalhao, Rose Meire Costa
AU  - Brancalhao RMC
AD  - Programa de Biociencias e Saude, Universidade Estadual do Oeste do Parana 
      (Unioeste), Cascavel, PR, Brazil.
FAU - Bertolini, Gladson Ricardo Flor
AU  - Bertolini GRF
AD  - Programa de Biociencias e Saude, Universidade Estadual do Oeste do Parana 
      (Unioeste), Cascavel, PR, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180404
PL  - Brazil
TA  - Rev Bras Ortop
JT  - Revista brasileira de ortopedia
JID - 101660959
PMC - PMC5993878
OTO - NOTNLM
OT  - Exercise
OT  - Histology
OT  - Intercellular signaling peptides and proteins
OT  - Median nerve
OT  - Nerve regeneration
EDAT- 2018/06/13 06:00
MHDA- 2018/06/13 06:01
PMCR- 2018/04/04
CRDT- 2018/06/13 06:00
PHST- 2017/01/16 00:00 [received]
PHST- 2017/03/16 00:00 [accepted]
PHST- 2018/06/13 06:00 [entrez]
PHST- 2018/06/13 06:00 [pubmed]
PHST- 2018/06/13 06:01 [medline]
PHST- 2018/04/04 00:00 [pmc-release]
AID - S2255-4971(18)30045-4 [pii]
AID - 10.1016/j.rboe.2018.03.006 [doi]
PST - epublish
SO  - Rev Bras Ortop. 2018 Apr 4;53(3):276-280. doi: 10.1016/j.rboe.2018.03.006. 
      eCollection 2018 May-Jun.