PMID- 29893062
OWN - NLM
STAT- MEDLINE
DCOM- 20191003
LR  - 20191007
IS  - 1097-4687 (Electronic)
IS  - 0022-2887 (Linking)
VI  - 279
IP  - 8
DP  - 2018 Aug
TI  - Histological studies on the development of porcine tonsils after birth.
PG  - 1185-1193
LID - 10.1002/jmor.20839 [doi]
AB  - Tonsils form the topographically first immune barrier of an organism against the 
      invasion of pathogens. We used histology to study the development of tonsils of 
      pigs after birth. At birth, the tonsils consist of diffuse lymphoid tissue 
      without any lymphoid follicle aggregations. At the age of 7 days, lymphoid 
      follicles appeared in the soft palate tonsil. The lymphoid layer of the 
      nasopharyngeal tonsil, soft palate tonsil, and lingual tonsil became thicker, and 
      lymphoid follicles in the lamina propria were clearly visible at the age of 21 
      days. Secondary lymphoid follicles were present in the nasopharyngeal tonsil at 
      the age of 50 days, and in the soft palate tonsil at the age of 120 days. 
      Dendritic cells (DCs), CD3(+) T cells and IgA(+) B cells in the soft palate 
      tonsil, nasopharyngeal tonsil and lingual tonsil increased continuously, 
      especially during the first 21 days. The results suggested that tonsils have an 
      important role in local immune defense against invading antigens after birth and 
      will be beneficial for understanding the mechanisms of immunity in these animals 
      after nasal and oral vaccination.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Yang, Yunhan
AU  - Yang Y
AUID- ORCID: 0000-0001-8143-5919
AD  - MOE Joint International Research Laboratory of Animal Health and Food Safety, 
      College of veterinary medicine, Nanjing Agricultural University. Weigang 1 
      Nanjing, Jiangsu, 210095, People's Republic of China.
FAU - Jing, Yuchao
AU  - Jing Y
AD  - MOE Joint International Research Laboratory of Animal Health and Food Safety, 
      College of veterinary medicine, Nanjing Agricultural University. Weigang 1 
      Nanjing, Jiangsu, 210095, People's Republic of China.
FAU - Wang, Jialu
AU  - Wang J
AD  - MOE Joint International Research Laboratory of Animal Health and Food Safety, 
      College of veterinary medicine, Nanjing Agricultural University. Weigang 1 
      Nanjing, Jiangsu, 210095, People's Republic of China.
FAU - Yang, Qian
AU  - Yang Q
AD  - MOE Joint International Research Laboratory of Animal Health and Food Safety, 
      College of veterinary medicine, Nanjing Agricultural University. Weigang 1 
      Nanjing, Jiangsu, 210095, People's Republic of China.
LA  - eng
GR  - 31772777/National Natural Science Foundation of China/International
GR  - Priority Academic Program Development/International
GR  - Jiangsu Higher Education Institutions/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180611
PL  - United States
TA  - J Morphol
JT  - Journal of morphology
JID - 0406125
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/metabolism
MH  - Dendritic Cells/cytology
MH  - Immunoglobulin A/metabolism
MH  - Lymphoid Tissue/cytology
MH  - Palatine Tonsil/*cytology/*growth & development
MH  - Pharynx/cytology
MH  - Swine/*growth & development
MH  - T-Lymphocytes/metabolism
OTO - NOTNLM
OT  - nasal immunology
OT  - oral immunology
OT  - pig
EDAT- 2018/06/13 06:00
MHDA- 2019/10/08 06:00
CRDT- 2018/06/13 06:00
PHST- 2017/09/14 00:00 [received]
PHST- 2018/04/11 00:00 [revised]
PHST- 2018/04/21 00:00 [accepted]
PHST- 2018/06/13 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
PHST- 2018/06/13 06:00 [entrez]
AID - 10.1002/jmor.20839 [doi]
PST - ppublish
SO  - J Morphol. 2018 Aug;279(8):1185-1193. doi: 10.1002/jmor.20839. Epub 2018 Jun 11.