PMID- 29894999
OWN - NLM
STAT- MEDLINE
DCOM- 20181107
LR  - 20210109
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 177
IP  - 2
DP  - 2018
TI  - Grass-Allergic Children Frequently Show Asymptomatic Low-Level IgE 
      Co-Sensitization and Cross-Reactivity to Wheat.
PG  - 135-144
LID - 10.1159/000489610 [doi]
AB  - BACKGROUND: Specific immunoglobulin E (IgE) sensitization to wheat is more common 
      than a doctor's confirmed wheat allergy and is also frequently observed in grass 
      pollen-allergic patients (pollinosis patients). Thus, the objective of this study 
      was to investigate the level and feature of serological IgE cross-reactivity 
      between grass pollen and wheat in a cohort of pollinosis subjects with no 
      diagnosis of wheat allergy. METHODS: Seventy-two children, aged 5-17 years, with 
      a doctor's diagnosis of pollinosis, IgE towards grass pollen, and currently 
      eating wheat were recruited. Serum samples were analyzed for IgE against wheat, 
      timothy grass/wheat-specific allergen components, Pru p 3, and cross-reactive 
      carbohydrate determinants (CCD) and specific IgE-binding inhibition experiments 
      were performed. RESULTS: Sixty percent of the grass pollen subjects were 
      sensitized to wheat with a median of 0.5 kUA/L. Wheat-sensitized subjects were 
      more often sensitized to the two allergens, Phl p 12 and CCD, known to be 
      cross-reactive between grass and wheat. Sensitizations to seven wheat-specific 
      allergens derived from the gluten fraction were, with the exception of one 
      individual, only found in wheat-sensitized subjects. These subjects also more 
      often reported current and past history of allergy to staple foods (milk, egg, 
      wheat, soy, and fish). CONCLUSION: Wheat sensitization caused by cross-reactivity 
      but also by sensitization to wheat-specific allergens was common in the 
      grass-allergic children and also associated with allergy to staple foods other 
      than wheat. The results indicate the presence of a subgroup of pollinosis 
      patients with simultaneous sensitization to wheat and food allergy not only 
      caused by cross-reactions.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Nilsson, Nora
AU  - Nilsson N
AD  - Lung/Allergy Department, Karolinska Institutet and Karolinska University 
      Hospital, Astrid Lindgren Children's Hospital, Stockholm, Sweden.
AD  - Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
FAU - Nilsson, Caroline
AU  - Nilsson C
AD  - Department of Clinical Science and Education, Sodersjukhuset, Karolinska 
      Institutet and Sachs Children's Hospital, Stockholm, Sweden.
FAU - Ekoff, Helena
AU  - Ekoff H
AD  - Thermo Fisher Scientific, ImmunoDiagnostics, Uppsala, Sweden.
FAU - Wieser-Pahr, Sandra
AU  - Wieser-Pahr S
AD  - Division of Immunopathology, Department of Pathophysiology and Allergy Research, 
      Center of Pathophysiology, Infectiology and Immunology, Medical University of 
      Vienna, Vienna, Austria.
AD  - Christian Doppler Laboratory for the Development of Allergen Chips, Medical 
      University of Vienna, Vienna, Austria.
FAU - Borres, Magnus P
AU  - Borres MP
AD  - Thermo Fisher Scientific, ImmunoDiagnostics, Uppsala, Sweden.
AD  - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
FAU - Valenta, Rudolf
AU  - Valenta R
AD  - Division of Immunopathology, Department of Pathophysiology and Allergy Research, 
      Center of Pathophysiology, Infectiology and Immunology, Medical University of 
      Vienna, Vienna, Austria.
AD  - Christian Doppler Laboratory for the Development of Allergen Chips, Medical 
      University of Vienna, Vienna, Austria.
FAU - Hedlin, Gunilla
AU  - Hedlin G
AD  - Lung/Allergy Department, Karolinska Institutet and Karolinska University 
      Hospital, Astrid Lindgren Children's Hospital, Stockholm, Sweden.
AD  - Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
FAU - Sjolander, Sigrid
AU  - Sjolander S
AD  - Thermo Fisher Scientific, ImmunoDiagnostics, Uppsala, Sweden.
LA  - eng
GR  - F 4605/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
DEP - 20180612
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Child
MH  - Child, Preschool
MH  - *Cross Reactions
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*complications
MH  - Immunoglobulin E/*blood/immunology
MH  - Male
MH  - Phleum/immunology
MH  - Poaceae/*immunology
MH  - Triticum/*immunology
MH  - Wheat Hypersensitivity/*complications
OTO - NOTNLM
OT  - Allergy
OT  - Children
OT  - Cross-reactivity
OT  - Grass
OT  - Immunoglobulin E
OT  - Inhibition
OT  - Wheat
EDAT- 2018/06/13 06:00
MHDA- 2018/11/08 06:00
CRDT- 2018/06/13 06:00
PHST- 2018/04/13 00:00 [received]
PHST- 2018/04/16 00:00 [accepted]
PHST- 2018/06/13 06:00 [pubmed]
PHST- 2018/11/08 06:00 [medline]
PHST- 2018/06/13 06:00 [entrez]
AID - 000489610 [pii]
AID - 10.1159/000489610 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2018;177(2):135-144. doi: 10.1159/000489610. Epub 2018 
      Jun 12.