PMID- 29895003
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20240412
IS  - 1423-0143 (Electronic)
IS  - 1420-4096 (Linking)
VI  - 43
IP  - 3
DP  - 2018
TI  - Depression and Physical Frailty Have Additive Effect on the Nutritional Status 
      and Clinical Outcome of Chinese Peritoneal Dialysis.
PG  - 914-923
LID - 10.1159/000490470 [doi]
AB  - BACKGROUND/AIMS: Frailty and depression both contribute to malnutrition and 
      adverse clinical outcome of peritoneal dialysis (PD) patients. However, their 
      interaction is incompletely defined. METHODS: We studied 178 adult Chinese PD 
      patients. Physical frailty was assessed by a validated in-house questionnaire; 
      depressive symptoms was screened by the Geriatric Depression Scale; nutritional 
      status was determined by subjective global assessment (SGA) and malnutrition 
      inflammation score (MIS). All patients were followed for up to 24 months for 
      survival and hospitalization analysis. RESULTS: There were 111 patients (62.4%) 
      physically frail, amongst those 48 (43.2%) had depressive symptoms. Only 1 
      patient had depressive symptoms without frailty. There was an additive effect of 
      depressive symptoms and physical frailty on nutritional status. For the groups 
      with no frailty, frail but no depressive symptoms, and frail with depressive 
      symptoms, serum albumin decreased in a stepwise manner (35.8 +/- 5.6, 34.9 +/- 4.4, 
      and 32.9 +/- 5.3 g/L, respectively, p=0.025); overall SGA score was 5.75 +/- 0.61, 
      5.41 +/- 0.59, and 5.04 +/- 0.77, respectively (p< 0.0001), and MIS was 5.12 +/- 2.30, 
      7.13 +/- 3.22, and 9.48 +/- 3.97, respectively (p< 0.0001). At 24 months, patient 
      survival was 86.6%, 71.4%, and 62.5% for patients with no frailty, frail but no 
      depressive symptoms, and frail with depressive symptoms, respective (p=0.001). 
      The median number of hospital stay was 8.04 (inter-quartile range [IQR] 0.91 - 
      19.42), 14.05 (IQR 3.57 - 37.27), and 26.62 (IQR 10.65 - 61.18) days per year of 
      follow up, respectively (p< 0.0001). CONCLUSION: Physical frailty and depressive 
      symptoms are both common in Chinese PD patients, and they have additive adverse 
      effect on the nutritional status and clinical outcome.
CI  - (c) 2018 The Author(s). Published by S. Karger AG, Basel.
FAU - Szeto, Cheuk-Chun
AU  - Szeto CC
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, 
      ccszeto@cuhk.edu.hk.
FAU - Chan, Gordon Chun-Kau
AU  - Chan GC
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Ng, Jack Kit-Chung
AU  - Ng JK
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Chow, Kai-Ming
AU  - Chow KM
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Kwan, Bonnie Ching-Ha
AU  - Kwan BC
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Cheng, Phyllis Mei-Shan
AU  - Cheng PM
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Kwong, Vickie Wai-Ki
AU  - Kwong VW
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Law, Man-Ching
AU  - Law MC
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Leung, Chi-Bon
AU  - Leung CB
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Li, Philip Kam-Tao
AU  - Li PK
AD  - Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & 
      Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
LA  - eng
PT  - Journal Article
DEP - 20180607
PL  - Switzerland
TA  - Kidney Blood Press Res
JT  - Kidney & blood pressure research
JID - 9610505
SB  - IM
MH  - Acute Kidney Injury/drug therapy
MH  - Aged
MH  - Asian People
MH  - Depression/*complications
MH  - Female
MH  - Frailty/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nutritional Status
MH  - *Peritoneal Dialysis
MH  - Renal Insufficiency, Chronic/therapy
MH  - Reperfusion Injury/drug therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Psychiatry
OT  - Renal failure
OT  - Survival
EDAT- 2018/06/13 06:00
MHDA- 2018/10/23 06:00
CRDT- 2018/06/13 06:00
PHST- 2017/12/14 00:00 [received]
PHST- 2018/05/30 00:00 [accepted]
PHST- 2018/06/13 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/06/13 06:00 [entrez]
AID - 000490470 [pii]
AID - 10.1159/000490470 [doi]
PST - ppublish
SO  - Kidney Blood Press Res. 2018;43(3):914-923. doi: 10.1159/000490470. Epub 2018 Jun 
      7.