PMID- 29896133
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 9
DP  - 2018
TI  - The Impact of Aging, Psychotic Symptoms, Medication, and Brain-Derived 
      Neurotrophic Factor on Cognitive Impairment in Japanese Chronic Schizophrenia 
      Patients.
PG  - 232
LID - 10.3389/fpsyt.2018.00232 [doi]
LID - 232
AB  - Background: Cognitive impairment in schizophrenia can result in considerable 
      difficulty in performing functions of daily life or social rehabilitation. 
      Cognitive impairment in schizophrenia is related to various factors, such as the 
      psychotic severity, aging, medication, and brain-derived neurotrophic factor 
      (BDNF). To date, however, no studies investigating the impact of these factors on 
      cognitive functioning in chronic schizophrenia patients have been performed. 
      Objective: The aim of this study is to identify those factors that influence the 
      cognitive functioning in patients with chronic schizophrenia. Methods: Sixty-five 
      of 116 long-term hospitalized chronic schizophrenia patients (63.8 +/- 12.1 years 
      old, M/F = 29/36) were enrolled this cross-sectional study. We investigated the 
      relationship among the patients' age, psychotic severity, treatment medication, 
      serum BDNF levels, and cognitive functioning (measured by the Japanese-language 
      version of the Brief Assessment of Cognition in Schizophrenia; BACS-J). 
      Additionally, we performed a multivariable linear regression analysis. Results: 
      According to the partial correlation analysis, certain parameters [i.e., age, 
      chlorpromazine (CP) equivalent, biperiden (BP) equivalent, and serum BDNF] were 
      significantly correlated with cognitive functioning, including working memory 
      (WM), motor function (MF), attention and processing speed (AP), and executive 
      function (EF). For the multivariate analysis, the MF component, which had the 
      highest correlation, was selected as the dependent variable, and the independent 
      variables included age, Manchester Scale for chronic psychosis (ManS) total 
      score, CP equivalent, BP equivalent, serum BDNF, estimated full scale IQ, and 
      years of education. According to the multiple regression analysis of this model, 
      R (multiple regression coefficient) was 0.542, the adjusted R(2) (coefficient of 
      determination) was 0.201, and only BP equivalent (beta = -0.305, p = 0.030), but not 
      age, ManS score, CP equivalent, or serum BDNF, could significantly explain MF at 
      the 5% significant level. Conclusion: In conclusion, aging, medication 
      (administering more antipsychotics or anticholinergics), and serum BDNF 
      concentration are significantly correlated with cognitive dysfunction in chronic 
      schizophrenia patients but not with the severity of psychotic symptoms. 
      Furthermore, only the anticholinergic dosage had a significant causal 
      relationship with MF. Thus, the use of anticholinergics in chronic schizophrenia 
      patients with deteriorating cognitive functioning must be reconsidered.
FAU - Atake, Kiyokazu
AU  - Atake K
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Nakamura, Tomoyuki
AU  - Nakamura T
AD  - Department of Neuropsychiatry, Kurume University, Kurume, Japan.
FAU - Ueda, Nobuhisa
AU  - Ueda N
AD  - Tsutsumi Hospital, Okagaki, Japan.
FAU - Hori, Hikaru
AU  - Hori H
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Katsuki, Asuka
AU  - Katsuki A
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180529
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5987164
OTO - NOTNLM
OT  - Japanese-language version of the Brief Assessment of Cognition in Schizophrenia
OT  - aging
OT  - brain-derived neurotrophic factor
OT  - cognitive impairment
OT  - schizophrenia
EDAT- 2018/06/14 06:00
MHDA- 2018/06/14 06:01
PMCR- 2018/05/29
CRDT- 2018/06/14 06:00
PHST- 2017/12/29 00:00 [received]
PHST- 2018/05/11 00:00 [accepted]
PHST- 2018/06/14 06:00 [entrez]
PHST- 2018/06/14 06:00 [pubmed]
PHST- 2018/06/14 06:01 [medline]
PHST- 2018/05/29 00:00 [pmc-release]
AID - 10.3389/fpsyt.2018.00232 [doi]
PST - epublish
SO  - Front Psychiatry. 2018 May 29;9:232. doi: 10.3389/fpsyt.2018.00232. eCollection 
      2018.