PMID- 29896479
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 5
DP  - 2018
TI  - Impact of Rye Kernel-Based Evening Meal on Microbiota Composition of Young 
      Healthy Lean Volunteers With an Emphasis on Their Hormonal and Appetite 
      Regulations, and Blood Levels of Brain-Derived Neurotrophic Factor.
PG  - 45
LID - 10.3389/fnut.2018.00045 [doi]
LID - 45
AB  - Rye kernel bread (RKB) evening meals improve glucose tolerance, enhance appetite 
      regulation and increase satiety in healthy volunteers. These beneficial effects 
      on metabolic responses have been shown to be associated with increased gut 
      fermentation. The present study aimed to elucidate if RKB evening meals may cause 
      rapid alterations in microbiota composition that might be linked to metabolic-, 
      immune-, and appetite- parameters. Gut-brain axis interaction was also studied by 
      relating microbiota composition to amount of brain-derived neurotrophic factor 
      (BDNF) in blood plasma. Nineteen healthy volunteers, ten women and nine men aged 
      22-29 years, BMI < 25 (NCT02093481) participated in the study performed in a 
      crossover design. Each person was assigned to either white wheat bread (WWB) or 
      RKB intake as a single evening meal or three consecutive evenings. Stool and 
      blood samples as well as subjective appetite ratings were obtained the subsequent 
      morning after each test occasion, resulting in four independent collections per 
      participant (n = 76). DNA was extracted from the fecal samples and V4 
      hypervariable region of the bacterial 16S rRNA genes was sequenced using next 
      generation sequencing technology. Higher abundance of Prevotella and 
      Faecalibacterium with simultaneous reduction of Bacteroides spp. were observed 
      after RKB meals compared to WWB. The associations between metabolic test 
      variables and microbiota composition showed a positive correlation between 
      Bacteroides and adiponectin levels, whereas only Prevotella genus was found to 
      have positive association with plasma levels of BDNF. These novel findings in 
      gut-brain interactions might be of importance, since decreased levels of BDNF, 
      that plays an essential role in brain function, contribute to the pathogenesis of 
      several major neurodisorders, including Alzheimer's. Thus, daily consumption of 
      Faecalibacterium- and/or Prevotella-favoring meals should be investigated further 
      for their potential to prevent neurodegenerative processes in the brain.
FAU - Prykhodko, Olena
AU  - Prykhodko O
AD  - Food for Health Science Centre, Lund University, Lund, Sweden.
AD  - Department of Food Technology, Engineering and Nutrition, Lund University, Lund, 
      Sweden.
FAU - Sandberg, Jonna
AU  - Sandberg J
AD  - Food for Health Science Centre, Lund University, Lund, Sweden.
AD  - Department of Food Technology, Engineering and Nutrition, Lund University, Lund, 
      Sweden.
FAU - Burleigh, Stephen
AU  - Burleigh S
AD  - Food for Health Science Centre, Lund University, Lund, Sweden.
AD  - Department of Food Technology, Engineering and Nutrition, Lund University, Lund, 
      Sweden.
FAU - Bjorck, Inger
AU  - Bjorck I
AD  - Food for Health Science Centre, Lund University, Lund, Sweden.
FAU - Nilsson, Anne
AU  - Nilsson A
AD  - Food for Health Science Centre, Lund University, Lund, Sweden.
AD  - Department of Food Technology, Engineering and Nutrition, Lund University, Lund, 
      Sweden.
FAU - Fak Hallenius, Frida
AU  - Fak Hallenius F
AD  - Food for Health Science Centre, Lund University, Lund, Sweden.
AD  - Department of Food Technology, Engineering and Nutrition, Lund University, Lund, 
      Sweden.
LA  - eng
PT  - Journal Article
DEP - 20180529
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC5986961
OTO - NOTNLM
OT  - Bacteroides
OT  - Faecalibacterium
OT  - Prevotella
OT  - gut-brain axis
OT  - rye kernel bread
EDAT- 2018/06/14 06:00
MHDA- 2018/06/14 06:01
PMCR- 2018/01/01
CRDT- 2018/06/14 06:00
PHST- 2018/01/31 00:00 [received]
PHST- 2018/05/08 00:00 [accepted]
PHST- 2018/06/14 06:00 [entrez]
PHST- 2018/06/14 06:00 [pubmed]
PHST- 2018/06/14 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2018.00045 [doi]
PST - epublish
SO  - Front Nutr. 2018 May 29;5:45. doi: 10.3389/fnut.2018.00045. eCollection 2018.