PMID- 29896669
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20181120
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1045
DP  - 2018
TI  - Chromosomal Integration by Human Herpesviruses 6A and 6B.
PG  - 209-226
LID - 10.1007/978-981-10-7230-7_10 [doi]
AB  - Upon infection and depending on the infected cell type, human herpesvirus 6A 
      (HHV-6A) and 6B (HHV-6B) can replicate or enter a state of latency. HHV-6A and 
      HHV-6B can integrate their genomes into host chromosomes as one way to establish 
      latency. Viral integration takes place near the subtelomeric/telomeric junction 
      of chromosomes. When HHV-6 infection and integration occur in gametes, the virus 
      can be genetically transmitted. Inherited chromosomally integrated HHV-6 
      (iciHHV-6)-positive individuals carry one integrated HHV-6 copy per somatic cell. 
      The prevalence of iciHHV-6(+) individuals varies between 0.6% and 2%, depending 
      on the geographical region sampled. In this chapter, the mechanisms leading to 
      viral integration and reactivation from latency, as well as some of the 
      biological and medical consequences associated with iciHHV-6, were discussed.
FAU - Flamand, Louis
AU  - Flamand L
AD  - Division of Infectious and Immune Diseases, CHU de Quebec Research Center, QC, 
      Quebec, Canada. Louis.Flamand@crchul.ulaval.ca.
AD  - Department of Microbiology, Infectious Disease and Immunology, Faculty of 
      Medicine, Universite Laval, QC, Quebec, Canada. Louis.Flamand@crchul.ulaval.ca.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Chromosomes, Human/*virology
MH  - DNA, Viral/genetics/metabolism
MH  - Herpesvirus 6, Human/genetics/*physiology
MH  - Humans
MH  - Roseolovirus Infections/*virology
MH  - Telomere/virology
MH  - *Virus Integration
OTO - NOTNLM
OT  - Chromosomal integration
OT  - Chromosomes
OT  - HHV-6
OT  - Telomeres
OT  - Telomeric motifs
OT  - iciHHV-6
EDAT- 2018/06/14 06:00
MHDA- 2018/11/21 06:00
CRDT- 2018/06/14 06:00
PHST- 2018/06/14 06:00 [entrez]
PHST- 2018/06/14 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
AID - 10.1007/978-981-10-7230-7_10 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2018;1045:209-226. doi: 10.1007/978-981-10-7230-7_10.