PMID- 29897294
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20211204
IS  - 1522-1210 (Electronic)
IS  - 0031-9333 (Print)
IS  - 0031-9333 (Linking)
VI  - 98
IP  - 3
DP  - 2018 Jul 1
TI  - DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.
PG  - 1765-1803
LID - 10.1152/physrev.00064.2017 [doi]
AB  - DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein 
      (DEPTOR) is an important modulator of mTOR, a kinase at the center of two 
      important protein complexes named mTORC1 and mTORC2. These highly studied 
      complexes play essential roles in regulating growth, metabolism, and immunity in 
      response to mitogens, nutrients, and cytokines. Defects in mTOR signaling have 
      been associated with the development of many diseases, including cancer and 
      diabetes, and approaches aiming at modulating mTOR activity are envisioned as an 
      attractive strategy to improve human health. DEPTOR interaction with mTOR 
      represses its kinase activity and rewires the mTOR signaling pathway. Over the 
      last years, several studies have revealed key roles for DEPTOR in numerous 
      biological and pathological processes. Here, we provide the current state of the 
      knowledge regarding the cellular and physiological functions of DEPTOR by 
      focusing on its impact on the mTOR pathway and its role in promoting health and 
      disease.
FAU - Caron, Alexandre
AU  - Caron A
AUID- ORCID: 0000-0001-6939-6136
AD  - Department of Internal Medicine, Division of Hypothalamic Research, The 
      University of Texas Southwestern Medical Center , Dallas, Texas ; Transplant 
      Research Program, Boston Children's Hospital , Boston, Massachusetts ; Department 
      of Pediatrics, Harvard Medical School , Boston, Massachusetts ; Centre de 
      Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec 
      (CRIUCPQ), Faculte de Medecine, Universite Laval , Quebec , Canada ; and Centre 
      de Recherche sur le Cancer de l'Universite Laval, Universite Laval , Quebec , 
      Canada.
FAU - Briscoe, David M
AU  - Briscoe DM
AD  - Department of Internal Medicine, Division of Hypothalamic Research, The 
      University of Texas Southwestern Medical Center , Dallas, Texas ; Transplant 
      Research Program, Boston Children's Hospital , Boston, Massachusetts ; Department 
      of Pediatrics, Harvard Medical School , Boston, Massachusetts ; Centre de 
      Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec 
      (CRIUCPQ), Faculte de Medecine, Universite Laval , Quebec , Canada ; and Centre 
      de Recherche sur le Cancer de l'Universite Laval, Universite Laval , Quebec , 
      Canada.
FAU - Richard, Denis
AU  - Richard D
AD  - Department of Internal Medicine, Division of Hypothalamic Research, The 
      University of Texas Southwestern Medical Center , Dallas, Texas ; Transplant 
      Research Program, Boston Children's Hospital , Boston, Massachusetts ; Department 
      of Pediatrics, Harvard Medical School , Boston, Massachusetts ; Centre de 
      Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec 
      (CRIUCPQ), Faculte de Medecine, Universite Laval , Quebec , Canada ; and Centre 
      de Recherche sur le Cancer de l'Universite Laval, Universite Laval , Quebec , 
      Canada.
FAU - Laplante, Mathieu
AU  - Laplante M
AD  - Department of Internal Medicine, Division of Hypothalamic Research, The 
      University of Texas Southwestern Medical Center , Dallas, Texas ; Transplant 
      Research Program, Boston Children's Hospital , Boston, Massachusetts ; Department 
      of Pediatrics, Harvard Medical School , Boston, Massachusetts ; Centre de 
      Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec 
      (CRIUCPQ), Faculte de Medecine, Universite Laval , Quebec , Canada ; and Centre 
      de Recherche sur le Cancer de l'Universite Laval, Universite Laval , Quebec , 
      Canada.
LA  - eng
GR  - R01 AI136503/AI/NIAID NIH HHS/United States
GR  - R21 AI129168/AI/NIAID NIH HHS/United States
GR  - MOP374552/Canadian Institutes of Health Research/International
GR  - R21 AI114223/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Physiol Rev
JT  - Physiological reviews
JID - 0231714
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 2.7.1.1 (DEPTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Aging/metabolism
MH  - Animals
MH  - Humans
MH  - Immunity
MH  - Intracellular Signaling Peptides and Proteins/chemistry/*metabolism
MH  - Molecular Structure
MH  - Neoplasms/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC6335100
EDAT- 2018/06/14 06:00
MHDA- 2018/12/12 06:00
PMCR- 2019/07/01
CRDT- 2018/06/14 06:00
PHST- 2018/06/14 06:00 [entrez]
PHST- 2018/06/14 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - PRV-00064-2017 [pii]
AID - 10.1152/physrev.00064.2017 [doi]
PST - ppublish
SO  - Physiol Rev. 2018 Jul 1;98(3):1765-1803. doi: 10.1152/physrev.00064.2017.