PMID- 29897580
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20190401
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 103
IP  - 4
DP  - 2018 Apr 1
TI  - Recent Topics Around Multiple Endocrine Neoplasia Type 1.
PG  - 1296-1301
LID - 10.1210/jc.2017-02340 [doi]
AB  - INTRODUCTION: Multiple endocrine neoplasia type 1 (MEN1) is complex with regard 
      to clinical expressions, management, and molecular pathways. Advances are being 
      made broadly and in focused aspects. Selected topics are presented for their 
      developments since publication of the most recent MEN1 consensus guidelines 6 
      years ago. METHODS: Topics were selected for clinical impact or broad interest or 
      both. For each topic, information was obtained from original reports and reviews. 
      RESULTS: The selected topics are as follows: tumor behavior and breast cancer in 
      MEN1; foregut neuroectoderm tumor screening, biomarkers periodically to detect 
      tumor emergence of foregut neuroectoderm tumors, 68Ga dotatate positron emission 
      tomography/computed tomography for pancreatic and duodenal neuroectodermal tumor 
      imaging, and glucagon-like peptide-1 receptor scintigraphy for insulinoma; 
      therapy, the size of pancreatic neuroendocrine tumor (NET) as one criterion for 
      surgery, minimally invasive surgery of pancreatic NETs, and 177Lu dotatate 
      therapy; MEN1 gene, the search for the MEN1/menin pathway and MEN1 or GCM2 
      mutation in familial isolated hyperparathyroidism, and MEN1 mutation-positive vs 
      mutation-negative cases of MEN1 are different. CONCLUSIONS: MEN1 topics are a 
      rich and fast-moving area. Important highlights stand out, and major and rapid 
      advances will continue into the near future.
FAU - Marx, Stephen J
AU  - Marx SJ
AD  - Eunice Kennedy Shriver National Institute of Child Health and Human Development, 
      National Institutes of Health, Bethesda, Maryland.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (GCM2 protein, human)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Cell Transformation, Neoplastic/genetics
MH  - Early Detection of Cancer/methods
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/genetics/*therapy
MH  - Mutation
MH  - Nuclear Proteins/genetics
MH  - Proto-Oncogene Proteins/genetics
MH  - Transcription Factors/genetics
PMC - PMC6276662
EDAT- 2018/06/14 06:00
MHDA- 2018/10/10 06:00
PMCR- 2019/04/01
CRDT- 2018/06/14 06:00
PHST- 2017/10/25 00:00 [received]
PHST- 2018/02/02 00:00 [accepted]
PHST- 2018/06/14 06:00 [entrez]
PHST- 2018/06/14 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 4963823 [pii]
AID - jcem_201702340 [pii]
AID - 10.1210/jc.2017-02340 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2018 Apr 1;103(4):1296-1301. doi: 10.1210/jc.2017-02340.