PMID- 29898192 OWN - NLM STAT- MEDLINE DCOM- 20180918 LR - 20191231 IS - 1809-452X (Electronic) IS - 1516-4446 (Print) IS - 1516-4446 (Linking) VI - 40 IP - 4 DP - 2018 Oct-Dec TI - Effects of cognitive-behavioral therapy on neurotrophic factors in patients with major depressive disorder. PG - 361-366 LID - 10.1590/1516-4446-2017-2357 [doi] AB - OBJECTIVE: To correlate neurotrophic factors - brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and beta-nerve growth factor (beta-NGF) - and severity of depressive symptoms in patients diagnosed with major depressive disorder (MDD) undergoing cognitive-behavioral therapy (CBT). METHODS: In this quasi-experimental study, participants were selected by convenience and received 16 sessions of CBT. The outcomes of interest were severity of depressive symptoms and changes in neurotrophic factor levels after CBT. The differences between variables before and after treatment (deltas) were analyzed. RESULTS: Patients had significant changes in symptom severity after treatment. No significant associations were found between Beck Depression Inventory II (BDI-II) scores and any independent variable. No correlations were observed between BDNF or GDNF levels and BDI scores before or after treatment, although there was a trend toward significant differences in beta-NGF levels. CONCLUSION: BDNF, beta-NGF, and GDNF were not influenced by the effects of CBT on depressive symptoms. FAU - da Silva, Sally K AU - da Silva SK AD - Departamento de Saude e Comportamento, Universidade Catolica de Pelotas, Pelotas, RS, Brazil. FAU - Wiener, Carolina AU - Wiener C AD - Departamento de Saude e Comportamento, Universidade Catolica de Pelotas, Pelotas, RS, Brazil. FAU - Ghisleni, Gabriele AU - Ghisleni G AD - Departamento de Saude e Comportamento, Universidade Catolica de Pelotas, Pelotas, RS, Brazil. FAU - Oses, Jean P AU - Oses JP AD - Departamento de Saude e Comportamento, Universidade Catolica de Pelotas, Pelotas, RS, Brazil. FAU - Jansen, Karen AU - Jansen K AD - Departamento de Saude e Comportamento, Universidade Catolica de Pelotas, Pelotas, RS, Brazil. FAU - Molina, Mariane L AU - Molina ML AD - Departamento de Saude e Comportamento, Universidade Catolica de Pelotas, Pelotas, RS, Brazil. FAU - Silva, Ricardo AU - Silva R AD - Departamento de Saude e Comportamento, Universidade Catolica de Pelotas, Pelotas, RS, Brazil. FAU - Souza, Luciano D AU - Souza LD AD - Departamento de Saude e Comportamento, Universidade Catolica de Pelotas, Pelotas, RS, Brazil. LA - eng PT - Journal Article DEP - 20180611 PL - Brazil TA - Braz J Psychiatry JT - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) JID - 100895975 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (GDNF protein, human) RN - 0 (Glial Cell Line-Derived Neurotrophic Factor) RN - 0 (NGF protein, human) RN - 0 (Nerve Growth Factors) RN - 7171WSG8A2 (BDNF protein, human) RN - 9061-61-4 (Nerve Growth Factor) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Cognitive Behavioral Therapy/*methods MH - Depressive Disorder, Major/*blood/diagnosis/psychology MH - Female MH - Glial Cell Line-Derived Neurotrophic Factor/*blood MH - Humans MH - Male MH - Middle Aged MH - Nerve Growth Factor/*blood MH - Nerve Growth Factors/*blood MH - Non-Randomized Controlled Trials as Topic MH - Psychiatric Status Rating Scales MH - Severity of Illness Index MH - Socioeconomic Factors MH - Young Adult PMC - PMC6899377 COIS- The authors report no conflicts of interest. EDAT- 2018/06/14 06:00 MHDA- 2018/09/19 06:00 PMCR- 2018/06/11 CRDT- 2018/06/14 06:00 PHST- 2017/06/05 00:00 [received] PHST- 2017/07/26 00:00 [accepted] PHST- 2018/06/14 06:00 [pubmed] PHST- 2018/09/19 06:00 [medline] PHST- 2018/06/14 06:00 [entrez] PHST- 2018/06/11 00:00 [pmc-release] AID - S1516-44462018005005105 [pii] AID - 10.1590/1516-4446-2017-2357 [doi] PST - ppublish SO - Braz J Psychiatry. 2018 Oct-Dec;40(4):361-366. doi: 10.1590/1516-4446-2017-2357. Epub 2018 Jun 11.