PMID- 29898609
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20181217
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 78
IP  - 5
DP  - 2018 Sep
TI  - Verification study on the NORIP LDH reference intervals with a proposed new upper 
      reference limit.
PG  - 421-427
LID - 10.1080/00365513.2018.1481223 [doi]
AB  - We verified the lactate dehydrogenase (LDH) reference interval (RI) provided by 
      the Nordic Reference Interval Project (NORIP). The serum LDH concentration was 
      analysed on the Dimension Vista 1500 system with an IFCC method with a bias of 
      +2.1 % and +2.7 % against NFKK Reference Serum X and ERM-AD453/IFCC, 
      respectively, showing verification of transference of the NORIP RI. Selective 
      data mining in clinical laboratory information systems for retrospective serum 
      LDH test results was used to calculate an indirect RI. For the adult age group 
      (18 to <70 years) the limits of the interval was 127 U/L (90 % CI: 123-132 U/L) 
      and 240 U/L (90 % CI: 234-243 U/L). However, the NORIP upper limit for the adult 
      age group is 205 U/L (90 % CI: 198-210 U/L). Accordingly, 25.1 % of LDH test 
      results were above the NORIPs upper limit of 205 U/L. If LDH analysis was 
      requested by the hospital's medical departments, outpatient clinics or general 
      practitioners 29.2 %, 26.2 % and 20.9 %, respectively, were above the 205 U/L 
      limit. Differences in transport time before centrifugation of blood, and 
      different transport principles could not explain the relative high percent of 
      test results above the NORIP 205 U/L limit. The indirect finding of an upper 
      limit of 240 U/L (90 % CI: 234-243 U/L), and the relative high number of test 
      result >205 U/L, suggests that the NORIP upper limit should be adjusted.
FAU - Kristiansen, Soren
AU  - Kristiansen S
AUID- ORCID: 0000-0003-1851-5363
AD  - a Department of Clinical Biochemistry , Copenhagen University Hospital of 
      Nordsjaelland , Denmark.
FAU - Friis-Hansen, Lennart
AU  - Friis-Hansen L
AD  - a Department of Clinical Biochemistry , Copenhagen University Hospital of 
      Nordsjaelland , Denmark.
FAU - Antonio Juel Jensen, Claus
AU  - Antonio Juel Jensen C
AD  - a Department of Clinical Biochemistry , Copenhagen University Hospital of 
      Nordsjaelland , Denmark.
FAU - Ingemann Hansen, Steen
AU  - Ingemann Hansen S
AD  - a Department of Clinical Biochemistry , Copenhagen University Hospital of 
      Nordsjaelland , Denmark.
LA  - eng
PT  - Journal Article
DEP - 20180613
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Automation, Laboratory/*standards
MH  - Blood Specimen Collection/*standards
MH  - Data Mining
MH  - Denmark
MH  - Female
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood/*standards
MH  - Male
MH  - Middle Aged
MH  - Practice Guidelines as Topic
MH  - Reference Values
MH  - Retrospective Studies
MH  - Sex Factors
OTO - NOTNLM
OT  - Clinical laboratory information system
OT  - data mining
OT  - lactate dehydrogenase
OT  - reference value
OT  - verification study
EDAT- 2018/06/15 06:00
MHDA- 2018/12/18 06:00
CRDT- 2018/06/15 06:00
PHST- 2018/06/15 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/06/15 06:00 [entrez]
AID - 10.1080/00365513.2018.1481223 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2018 Sep;78(5):421-427. doi: 
      10.1080/00365513.2018.1481223. Epub 2018 Jun 13.