PMID- 29898743 OWN - NLM STAT- MEDLINE DCOM- 20190319 LR - 20231103 IS - 1472-6947 (Electronic) IS - 1472-6947 (Linking) VI - 18 IP - 1 DP - 2018 Jun 14 TI - Utility of social media and crowd-intelligence data for pharmacovigilance: a scoping review. PG - 38 LID - 10.1186/s12911-018-0621-y [doi] LID - 38 AB - BACKGROUND: A scoping review to characterize the literature on the use of conversations in social media as a potential source of data for detecting adverse events (AEs) related to health products. METHODS: Our specific research questions were (1) What social media listening platforms exist to detect adverse events related to health products, and what are their capabilities and characteristics? (2) What is the validity and reliability of data from social media for detecting these adverse events? MEDLINE, EMBASE, Cochrane Library, and relevant websites were searched from inception to May 2016. Any type of document (e.g., manuscripts, reports) that described the use of social media data for detecting health product AEs was included. Two reviewers independently screened citations and full-texts, and one reviewer and one verifier performed data abstraction. Descriptive synthesis was conducted. RESULTS: After screening 3631 citations and 321 full-texts, 70 unique documents with 7 companion reports available from 2001 to 2016 were included. Forty-six documents (66%) described an automated or semi-automated information extraction system to detect health product AEs from social media conversations (in the developmental phase). Seven pre-existing information extraction systems to mine social media data were identified in eight documents. Nineteen documents compared AEs reported in social media data with validated data and found consistent AE discovery in all except two documents. None of the documents reported the validity and reliability of the overall system, but some reported on the performance of individual steps in processing the data. The validity and reliability results were found for the following steps in the data processing pipeline: data de-identification (n = 1), concept identification (n = 3), concept normalization (n = 2), and relation extraction (n = 8). The methods varied widely, and some approaches yielded better results than others. CONCLUSIONS: Our results suggest that the use of social media conversations for pharmacovigilance is in its infancy. Although social media data has the potential to supplement data from regulatory agency databases; is able to capture less frequently reported AEs; and can identify AEs earlier than official alerts or regulatory changes, the utility and validity of the data source remains under-studied. TRIAL REGISTRATION: Open Science Framework ( https://osf.io/kv9hu/ ). FAU - Tricco, Andrea C AU - Tricco AC AUID- ORCID: 0000-0002-4114-8971 AD - Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, ON, M5B 1W8, Canada. triccoa@smh.ca. AD - Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, 6th Floor, 155 College St, Toronto, ON, M5T 3M7, Canada. triccoa@smh.ca. FAU - Zarin, Wasifa AU - Zarin W AD - Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, ON, M5B 1W8, Canada. FAU - Lillie, Erin AU - Lillie E AD - Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, ON, M5B 1W8, Canada. FAU - Jeblee, Serena AU - Jeblee S AD - Department of Computer Science, University of Toronto, 10 King's College Road, Toronto, ON, M5S 3G4, Canada. FAU - Warren, Rachel AU - Warren R AD - Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, ON, M5B 1W8, Canada. FAU - Khan, Paul A AU - Khan PA AD - Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, ON, M5B 1W8, Canada. FAU - Robson, Reid AU - Robson R AD - Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, ON, M5B 1W8, Canada. FAU - Pham, Ba' AU - Pham B AD - Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, ON, M5B 1W8, Canada. FAU - Hirst, Graeme AU - Hirst G AD - Department of Computer Science, University of Toronto, 10 King's College Road, Toronto, ON, M5S 3G4, Canada. FAU - Straus, Sharon E AU - Straus SE AD - Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, ON, M5B 1W8, Canada. AD - Department of Geriatric Medicine, Faculty of Medicine, University of Toronto, 27 Kings College Circle, Toronto, ON, M5S 1A1, Canada. LA - eng GR - DNM-137713/CIHR/Canada PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20180614 PL - England TA - BMC Med Inform Decis Mak JT - BMC medical informatics and decision making JID - 101088682 SB - IM MH - *Adverse Drug Reaction Reporting Systems MH - *Drug-Related Side Effects and Adverse Reactions MH - Humans MH - *Pharmacovigilance MH - *Social Media PMC - PMC6001022 OTO - NOTNLM OT - Adverse event OT - Data analytics OT - Drug safety OT - Knowledge synthesis OT - Social media OT - Surveillance COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Since this is a scoping review, ethics approval was not required. COMPETING INTERESTS: The authors declare that they have no competing interests. The study funder had no input into the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2018/06/15 06:00 MHDA- 2019/03/20 06:00 PMCR- 2018/06/14 CRDT- 2018/06/15 06:00 PHST- 2017/10/19 00:00 [received] PHST- 2018/05/31 00:00 [accepted] PHST- 2018/06/15 06:00 [entrez] PHST- 2018/06/15 06:00 [pubmed] PHST- 2019/03/20 06:00 [medline] PHST- 2018/06/14 00:00 [pmc-release] AID - 10.1186/s12911-018-0621-y [pii] AID - 621 [pii] AID - 10.1186/s12911-018-0621-y [doi] PST - epublish SO - BMC Med Inform Decis Mak. 2018 Jun 14;18(1):38. doi: 10.1186/s12911-018-0621-y.