PMID- 29900017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2150-0878 (Print)
IS  - 2150-0886 (Electronic)
IS  - 2150-0878 (Linking)
VI  - 8
IP  - 1
DP  - 2017 Jan-Feb
TI  - Understanding and Managing Immune-Related Adverse Events Associated With Immune 
      Checkpoint Inhibitors in Patients With Advanced Melanoma.
PG  - 58-72
AB  - The immune checkpoint inhibitors ipilimumab, nivolumab, and pembrolizumab 
      represent a substantial improvement in treating advanced melanoma but are 
      associated with adverse events (AEs) likely related to general immunologic 
      enhancement. To ensure that patients receive optimal benefit from these agents, 
      prompt assessment and treatment of AEs are essential. We review the efficacy and 
      safety profiles of these immune checkpoint inhibitors and describe guidelines for 
      managing immune-related AEs. We also present case studies describing the 
      management of toxicities in patients receiving immune checkpoint inhibitor 
      therapy. These cases illustrate the importance of collecting a detailed medical 
      history when administering immunotherapy, as this information is necessary to 
      establish baseline, inform monitoring, and determine the etiology of symptoms. 
      Advanced practice nurses and physician assistants are uniquely positioned to 
      educate patients on the early recognition of AEs and have an important role in 
      establishing appropriate monitoring and open dialogue among services.
FAU - Weinstein, Alyona
AU  - Weinstein A
AD  - Memorial Sloan Kettering Cancer Center, New York, New York, USA.
FAU - Gordon, Ruth-Ann
AU  - Gordon RA
AD  - Memorial Sloan Kettering Cancer Center, New York, New York, USA.
FAU - Kasler, Mary Kate
AU  - Kasler MK
AD  - Memorial Sloan Kettering Cancer Center, New York, New York, USA.
FAU - Burke, Matthew
AU  - Burke M
AD  - Yale University School of Medicine, New Haven, Connecticut, USA.
FAU - Ranjan, Smita
AU  - Ranjan S
AD  - University of Louisville, Louisville, Kentucky, USA.
FAU - Hodgetts, Jackie
AU  - Hodgetts J
AD  - Christie Hospital, Manchester, UK.
FAU - Reed, Vanessa
AU  - Reed V
AD  - Memorial Sloan Kettering Cancer Center, New York, New York, USA.
FAU - Shames, Yelena
AU  - Shames Y
AD  - Memorial Sloan Kettering Cancer Center, New York, New York, USA.
FAU - Prempeh-Keteku, Nana
AU  - Prempeh-Keteku N
AD  - Memorial Sloan Kettering Cancer Center, New York, New York, USA.
FAU - Lingard, Karla
AU  - Lingard K
AD  - Royal Marsden Hospital, London, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170101
PL  - United States
TA  - J Adv Pract Oncol
JT  - Journal of the advanced practitioner in oncology
JID - 101550346
PMC - PMC5995532
EDAT- 2017/01/01 00:00
MHDA- 2017/01/01 00:01
PMCR- 2017/01/01
CRDT- 2018/06/15 06:00
PHST- 2018/06/15 06:00 [entrez]
PHST- 2017/01/01 00:00 [pubmed]
PHST- 2017/01/01 00:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.6004/jadpro.2017.8.1.5 [doi]
PST - ppublish
SO  - J Adv Pract Oncol. 2017 Jan-Feb;8(1):58-72. doi: 10.6004/jadpro.2017.8.1.5. Epub 
      2017 Jan 1.