PMID- 29901037
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180626
LR  - 20180626
IS  - 1364-548X (Electronic)
IS  - 1359-7345 (Linking)
VI  - 54
IP  - 52
DP  - 2018 Jun 26
TI  - A one-pot process for the enantioselective synthesis of tetrahydroquinolines and 
      tetrahydroisoquinolines via asymmetric reductive amination (ARA).
PG  - 7247-7250
LID - 10.1039/c8cc03586e [doi]
AB  - Asymmetric reductive amination for the synthesis of both chiral 
      tetrahydroquinolines (THQs) and tetrahydroisoquinolines (THIQs) has been realized 
      with an Ir/ZhaoPhos catalytic system via a one-pot N-Boc 
      deprotection/intramolecular asymmetric reductive amination (ARA) sequence. 
      Control experiments reveal that HCl plays a vital role to the success of this 
      transformation. The HCl acid assists the removal of the N-Boc protecting group 
      and also provides chloride ions to interact with the thiourea moiety in ZhaoPhos, 
      thus leading to excellent reaction enantiocontrol.
FAU - Yang, Tao
AU  - Yang T
AD  - Department of Chemistry, Southern University of Science and Technology, Shenzhen, 
      518055, P. R. China. zhangxm@sustc.edu.cn.
FAU - Yin, Qin
AU  - Yin Q
FAU - Gu, Guoxian
AU  - Gu G
FAU - Zhang, Xumu
AU  - Zhang X
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chem Commun (Camb)
JT  - Chemical communications (Cambridge, England)
JID - 9610838
EDAT- 2018/06/15 06:00
MHDA- 2018/06/15 06:01
CRDT- 2018/06/15 06:00
PHST- 2018/06/15 06:00 [pubmed]
PHST- 2018/06/15 06:01 [medline]
PHST- 2018/06/15 06:00 [entrez]
AID - 10.1039/c8cc03586e [doi]
PST - ppublish
SO  - Chem Commun (Camb). 2018 Jun 26;54(52):7247-7250. doi: 10.1039/c8cc03586e.