PMID- 29902942
OWN - NLM
STAT- MEDLINE
DCOM- 20190319
LR  - 20190319
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 34
IP  - 11
DP  - 2018 Nov
TI  - The role of kisspeptin/neurokinin B/dynorphin neurons in pathomechanism of 
      vasomotor symptoms in postmenopausal women: from physiology to potential 
      therapeutic applications.
PG  - 913-919
LID - 10.1080/09513590.2018.1480711 [doi]
AB  - Women during perimenopausal period experience a range of symptoms, which 
      interfere with physical, sexual, and social life. About 65-75% of symptoms 
      connected with postmenopausal period are vasomotor symptoms (VMS), such as hot 
      flushes and night sweats. Hot flushes are subjective sensation of heat associated 
      with cutaneous vasodilatation and drop in core temperature. It is suspected that 
      VMS are strongly correlated with pulsatile oversecretion of 
      gonadotropin-releasing hormone (GnRH) and subsequently luteinizing hormone (LH). 
      Evidence has accumulated in parallel showing that lack of negative feedback of 
      steroid hormones synthesized in ovary causes overactivation of hypertrophied 
      kisspeptin/neurokinin B/dynorphin (KNDy) neurons, located in infundibular 
      nucleus. Oversecretion of both kisspeptin (KISS1) and neurokinin B (NKB), as well 
      as downregulation of dynorphin, plays dominant role in creation of GnRH pulses. 
      This in turn causes VMS. Administration of senktide, highly potent and selective 
      NK3R agonist, resulted in increase of serum LH concentration, induction of VMS, 
      increase in heart rate, and skin temperature in postmenopausal women. These 
      finding suggest that modulation of KNDy neurons may become new therapeutic 
      approach in the treatment of VMS.
FAU - Szeliga, Anna
AU  - Szeliga A
AD  - a Department of Gynecological Endocrinology , Poznan University of Medical 
      Sciences , Poznan , Poland.
FAU - Czyzyk, Adam
AU  - Czyzyk A
AD  - a Department of Gynecological Endocrinology , Poznan University of Medical 
      Sciences , Poznan , Poland.
FAU - Podfigurna, Agnieszka
AU  - Podfigurna A
AD  - a Department of Gynecological Endocrinology , Poznan University of Medical 
      Sciences , Poznan , Poland.
FAU - Genazzani, Andrea R
AU  - Genazzani AR
AD  - b Department of Reproductive Medicine and Child Development, Division of 
      Gynecology and Obstetrics , University of Pisa , Pisa , Italy.
FAU - Genazzani, Alessandro D
AU  - Genazzani AD
AD  - c Department of Obstetrics and Gynecology , Gynecological Endocrinology Center, 
      University of Modena and Reggio Emilia , Modena , Italy.
FAU - Meczekalski, Blazej
AU  - Meczekalski B
AD  - a Department of Gynecological Endocrinology , Poznan University of Medical 
      Sciences , Poznan , Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180614
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Kisspeptins)
RN  - 74913-18-1 (Dynorphins)
RN  - 86933-75-7 (Neurokinin B)
SB  - IM
MH  - Dynorphins/physiology
MH  - Feedback, Physiological
MH  - Female
MH  - Hot Flashes/drug therapy/*etiology
MH  - Humans
MH  - Hypothalamus/*physiology
MH  - Kisspeptins/physiology
MH  - Neurokinin B/physiology
MH  - Neurons/*physiology
MH  - Postmenopause/*physiology
MH  - Vasomotor System/*physiology
OTO - NOTNLM
OT  - KNDy
OT  - Neurokinin B
OT  - kisspeptin
OT  - menopause
OT  - vasomotor symptoms
EDAT- 2018/06/16 06:00
MHDA- 2019/03/20 06:00
CRDT- 2018/06/16 06:00
PHST- 2018/06/16 06:00 [pubmed]
PHST- 2019/03/20 06:00 [medline]
PHST- 2018/06/16 06:00 [entrez]
AID - 10.1080/09513590.2018.1480711 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2018 Nov;34(11):913-919. doi: 10.1080/09513590.2018.1480711. 
      Epub 2018 Jun 14.