PMID- 29903157
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20211204
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 46
IP  - 1
DP  - 2017 Jan
TI  - [Study of Rhizoma Darynaria on regulation of cellular immune function in 
      immunosuppressive mice].
PG  - 84-93
AB  - OBJECTIVE: To study the effect of Rhizoma Drynaria ethanol extract on regulation 
      of cellular immune functions in cyclophosphamide-induced immunosuppressive mice. 
      METHODS: A total of 60 kunming mice were randomly divided into six groups:normal 
      control group, model group, positive control group( levamisole, 0. 05 g / kg) and 
      low-, medium- and high-dose Rhizoma Drynaria ethanol extract-treated groups( 2. 
      5, 5, 10 g / kg). The mice in the four administration group were administered 
      with 10 mL / kg of the drug for 20 days. Except normal control group, the mice in 
      the other 5 groups were intraperitoneally injected( ip) with cyclophosphamide to 
      establish immunosuppression model. After the end of the experiment, the indices 
      of lymphocyte proliferation capacity and delayed type hypersensitivity were 
      detected, speen histological structure and Tlymphocyte subsets CD_4~+, CD_8~+T 
      cells in peripheral blood were measured. The relativemRNA expression of 
      Interleukin 4( IL-4) and Interferon-gamma( IFN-gamma) in the spleen tissues were 
      detected. RESULTS: Rhizoma Drynaria ethanol extract( 5, 10 g / kg) enhanced Con 
      Ainduced T-lymphocytes proliferative capacity and delayed type hypersensitivity, 
      increased CD_4~+T cells, CD_4~+/ CD_8~+ratio in peripheral blood, IFN-gamma mRNA 
      expression and IFN-gamma /IL-4 ratio, decreased CD_8~+T cells and IL-4 mRNA 
      expression. However, there was no obvious difference in LPS-induced B-lymphocyte 
      proliferation capacity. CONCLUSION: Rhizoma Drynaria ethanol extract could 
      regulate the cellular immune functions in cyclophosphamide-induced 
      immunosuppressive mice.
FAU - Zhao, Gan
AU  - Zhao G
AD  - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 
      530003, China.
FAU - He, Guanlan
AU  - He G
AD  - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 
      530003, China.
FAU - Lu, Chunyuan
AU  - Lu C
AD  - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 
      530003, China.
FAU - Lao, Lingling
AU  - Lao L
AD  - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 
      530003, China.
FAU - Wei, Jinbin
AU  - Wei J
AD  - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 
      530003, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (IL4 protein, human)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Plant Extracts)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/drug effects
MH  - Cyclophosphamide/*adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Immune System/*drug effects
MH  - Immunity, Cellular/*drug effects
MH  - Immunosuppression Therapy/*methods
MH  - Immunosuppressive Agents/*pharmacology
MH  - Interferon-gamma/blood
MH  - Interleukin-4/blood
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/administration & dosage/isolation & 
      purification/*pharmacology/toxicity
MH  - Spleen/drug effects/immunology
OTO - NOTNLM
OT  - Rhizoma drynaria ethanol extract
OT  - cellular immune
OT  - immunosuppression
OT  - regulation
EDAT- 2017/01/01 00:00
MHDA- 2018/10/12 06:00
CRDT- 2018/06/16 06:00
PHST- 2018/06/16 06:00 [entrez]
PHST- 2017/01/01 00:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2017 Jan;46(1):84-93.