PMID- 29904410
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 6
DP  - 2018 Jun
TI  - Influencing factors of NT-proBNP level inheart failure patients with different 
      cardiacfunctions and correlation with prognosis.
PG  - 5275-5280
LID - 10.3892/etm.2018.6114 [doi]
AB  - Factors influencing N-terminal pro-brain natriuretic peptide (NT-proBNP) level in 
      heart failure patients with different cardiac functions were identified to 
      explore the correlations with prognosis. Eighty heart failure patients with 
      different cardiac functions treated in Yixing People's Hospital from January 2016 
      to June 2017 were selected, and divided into two groups (group with cardiac 
      function in class II and below and group with cardiac function in class III and 
      above), according to the cardiac function classification established by New York 
      Heart Association (NYHA). Blood biochemical test and outcome analysis were 
      conducted to measure serum NT-proBNP and matrix metalloproteinase-9 (MMP-9) 
      levels in patients with different cardiac functions, and correlations between 
      levels of NT-proBNP and MMP-9 and left ventricular ejection fraction (LVEF) level 
      were analyzed in patients with different cardiac functions at the same time. In 
      addition, risk factors for heart failure in patients with different cardiac 
      functions were analyzed. Compared with the group with cardiac function in class 
      III and above, the group with cardiac function in class II and below had 
      significantly lower serum NT-proBNP and MMP-9 levels (p<0.05). For echocardiogram 
      indexes, left ventricular end-diastolic diameter (LVEDD) and left ventricular 
      end-systolic diameter (LVESD) in the group with cardiac function in class II and 
      below were obviously lower than those in the group with cardiac function in class 
      III and above (p<0.05), while LVEF was higher in group with cardiac function in 
      class II and below than that in group with cardiac function in class III and 
      above (p<0.05). NT-proBNP and MMP-9 levels were negatively correlated with LVEF 
      level [r=-0.8517 and -0.8517, respectively, p<0.001 (<0.05)]. Cardiac function in 
      class III and above, increased NT-proBNP, increased MMP-9 and decreased LVEF were 
      relevant risk factors and independent risk factors for heart failure in patients 
      with different cardiac functions. NT-proBNP and MMP-9 levels are negatively 
      correlated with LVEF in patients regardless of the cardiac function class. 
      Therefore, attention should be paid to patients who have cardiac function in 
      class III and above, increased NT-proBNP and MMP-9 levels and decreased LVEF in 
      clinical practices, so as to actively prevent and treat heart failure.
FAU - Xu, Liang
AU  - Xu L
AD  - Department of Cardiovascular Disease, Yixing People's Hospital, Yixing, Jiangsu 
      214200, P.R. China.
FAU - Chen, Yanchun
AU  - Chen Y
AD  - Department of Cardiovascular Disease, Yixing People's Hospital, Yixing, Jiangsu 
      214200, P.R. China.
FAU - Ji, Yanni
AU  - Ji Y
AD  - Department of Cardiovascular Disease, Yixing People's Hospital, Yixing, Jiangsu 
      214200, P.R. China.
FAU - Yang, Song
AU  - Yang S
AD  - Department of Cardiovascular Disease, Yixing People's Hospital, Yixing, Jiangsu 
      214200, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180502
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5996675
OTO - NOTNLM
OT  - N-terminal pro-brain natriuretic peptide
OT  - cardiac function
OT  - heart failure
OT  - influencing factors
EDAT- 2018/06/16 06:00
MHDA- 2018/06/16 06:01
PMCR- 2018/05/02
CRDT- 2018/06/16 06:00
PHST- 2017/10/19 00:00 [received]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/06/16 06:00 [entrez]
PHST- 2018/06/16 06:00 [pubmed]
PHST- 2018/06/16 06:01 [medline]
PHST- 2018/05/02 00:00 [pmc-release]
AID - ETM-0-0-6114 [pii]
AID - 10.3892/etm.2018.6114 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Jun;15(6):5275-5280. doi: 10.3892/etm.2018.6114. Epub 2018 May 
      2.