PMID- 29906037
OWN - NLM
STAT- MEDLINE
DCOM- 20180705
LR  - 20181202
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 99 Suppl 8
DP  - 2016 Nov
TI  - Effect of Curcumin on Characterization and Localization of Interleukin-13 and 
      Tumor Necrosis Factor-alpha in Liver of Diabetic Rats.
PG  - S187-S195
AB  - OBJECTIVE: To localize and characterize inflammatory markers: interleukin-13 
      (IL-13) and Tumor necrosis factor-alpha (TNF-alpha) in recovery livers after 
      curcumin supplementation in streptozotocin-induced diabetic rats. MATERIAL AND 
      METHOD: Induced diabetic male rats were achieved by streptozotocin intravenous 
      injection (50 mg/kg BW). The rats were divided into three groups, control rat 
      (C), diabetic rat (DM) and diabetic rat supplemented with curcumin (DMC) (200 
      mg/kg BW) that has been proposed for anti-inflammation and antioxidant 
      activities. After 12 weeks of curcumin supplementation, liver tissues were 
      collected and processed for hematoxylin & eosin staining and 
      immunohistochemistry. The localization and characterization of IL-13 and 
      TNF-alpha were investigated and compared among three groups in order to analyze 
      the efficiency of curcumin in recovering liver tissues. RESULTS: According DM 
      group, high intensity of IL-13 and TNF-alpha were accumulated around central 
      vein, along hepatic parenchyma, and at perivascular sinusoidal areas. In 
      contrast, the characterization of IL-13 and TNF-alpha in DMC were attenuated. 
      Then, the liver tissues were recovered and engaged by less severity sign of 
      inflammations. Therefore, dietary curcumin might have efficacy to ameliorate 
      diabetic complications in terms of controlling and modulating inflammatory 
      parameters, including IL-13, and TNF-alpha. CONCLUSION: Administration of 
      curcumin successfully attenuated liver tissue by means of decreased inflammatory 
      cytokine markers. The potential beneficial effects of curcumin have been shown to 
      decline the inflammatory of liver tissue, concerning illustration of IL-13, and 
      TNF-alpha. Therefore, the efficiency and achievement of curcumin might be applied 
      to be an alternative therapeutic agent in diabetic liver.
FAU - Satin, Kamolwan
AU  - Satin K
FAU - Petpiboolthai, Hattaya
AU  - Petpiboolthai H
FAU - Anupunpisit, Vipavee
AU  - Anupunpisit V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-13)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 5W494URQ81 (Streptozocin)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacology
MH  - Biomarkers/metabolism
MH  - Curcumin/administration & dosage/*pharmacology
MH  - Diabetes Mellitus, Experimental/*drug therapy/etiology
MH  - Dietary Supplements/analysis
MH  - Interleukin-13/*metabolism
MH  - Liver/*drug effects/immunology
MH  - Male
MH  - Organ Specificity
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin/pharmacology
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2016/11/01 00:00
MHDA- 2018/07/06 06:00
CRDT- 2018/06/16 06:00
PHST- 2018/06/16 06:00 [entrez]
PHST- 2016/11/01 00:00 [pubmed]
PHST- 2018/07/06 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2016 Nov;99 Suppl 8:S187-S195.