PMID- 29906515
OWN - NLM
STAT- MEDLINE
DCOM- 20190910
LR  - 20191101
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 74
DP  - 2018 Nov
TI  - TSPO expression and brain structure in the psychosis spectrum.
PG  - 79-85
LID - S0889-1591(18)30225-3 [pii]
LID - 10.1016/j.bbi.2018.06.009 [doi]
AB  - Psychosis is associated with abnormal structural changes in the brain including 
      decreased regional brain volumes and abnormal brain morphology. However, the 
      underlying causes of these structural abnormalities are less understood. The 
      immune system, including microglial activation, has been implicated in the 
      pathophysiology of psychosis. Although previous studies have suggested a 
      connection between peripheral proinflammatory cytokines and structural brain 
      abnormalities in schizophrenia, no in-vivo studies have investigated whether 
      microglial activation is also linked to brain structure alterations previously 
      observed in schizophrenia and its putative prodrome. In this study, we 
      investigated the link between mitochondrial 18 kDa translocator protein (TSPO) 
      and structural brain characteristics (i.e. regional brain volume, cortical 
      thickness, and hippocampal shape) in key brain regions such as dorsolateral 
      prefrontal cortex and hippocampus of a large group of participants (N = 90) 
      including individuals at clinical high risk (CHR) for psychosis, first-episode 
      psychosis (mostly antipsychotic-naive) patients, and healthy volunteers. The 
      participants underwent structural brain MRI scan and [(18)F]FEPPA positron 
      emission tomography (PET) targeting TSPO. A significant [(18)F]FEPPA 
      binding-by-group interaction was observed in morphological measures across the 
      left hippocampus. In first-episode psychosis, we observed associations between 
      [(18)F]FEPPA V(T) (total volume of distribution) and outward and inward 
      morphological alterations, respectively, in the dorsal and ventro-medial portions 
      of the left hippocampus. These associations were not significant in CHR or 
      healthy volunteers. There was no association between [(18)F]FEPPA V(T) and other 
      structural brain characteristics. Our findings suggest a link between TSPO 
      expression and alterations in hippocampal morphology in first-episode psychosis.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Hafizi, Sina
AU  - Hafizi S
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada.
FAU - Guma, Elisa
AU  - Guma E
AD  - Douglas Mental Health University Institute, McGill University, Montreal, QC, 
      Canada.
FAU - Koppel, Alex
AU  - Koppel A
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada.
FAU - Da Silva, Tania
AU  - Da Silva T
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada.
FAU - Kiang, Michael
AU  - Kiang M
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for 
      Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, 
      University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Houle, Sylvain
AU  - Houle S
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for 
      Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Wilson, Alan A
AU  - Wilson AA
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for 
      Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Rusjan, Pablo M
AU  - Rusjan PM
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for 
      Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, 
      University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Chakravarty, M Mallar
AU  - Chakravarty MM
AD  - Douglas Mental Health University Institute, McGill University, Montreal, QC, 
      Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada; 
      Department of Biomedical Engineering, McGill University, Montreal, QC, Canada.
FAU - Mizrahi, Romina
AU  - Mizrahi R
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for 
      Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, 
      University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, 
      University of Toronto, Toronto, Ontario, Canada. Electronic address: 
      romina.mizrahi@camhpet.ca.
LA  - eng
GR  - R01 MH100043/MH/NIMH NIH HHS/United States
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180612
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Receptors, GABA)
RN  - 0 (TSPO protein, human)
SB  - IM
CIN - Brain Behav Immun. 2018 Nov;74:43-44. PMID: 30077591
MH  - Adolescent
MH  - Adult
MH  - Brain/diagnostic imaging/*metabolism/*pathology
MH  - Case-Control Studies
MH  - Female
MH  - Hippocampus/diagnostic imaging/metabolism/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Positron-Emission Tomography/methods
MH  - Prefrontal Cortex/diagnostic imaging/pathology
MH  - Psychotic Disorders/diagnostic imaging/genetics/*metabolism/*pathology
MH  - Receptors, GABA/*biosynthesis/genetics/metabolism
MH  - Transcriptome
MH  - Young Adult
PMC - PMC6289857
MID - NIHMS978979
OTO - NOTNLM
OT  - Clinical high risk
OT  - MRI
OT  - PET
OT  - Psychosis
OT  - TSPO
COIS- Conflict of Interest The authors declare no conflict of interest.
EDAT- 2018/06/16 06:00
MHDA- 2019/09/11 06:00
PMCR- 2019/11/01
CRDT- 2018/06/16 06:00
PHST- 2018/02/05 00:00 [received]
PHST- 2018/06/06 00:00 [revised]
PHST- 2018/06/09 00:00 [accepted]
PHST- 2018/06/16 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
PHST- 2018/06/16 06:00 [entrez]
PHST- 2019/11/01 00:00 [pmc-release]
AID - S0889-1591(18)30225-3 [pii]
AID - 10.1016/j.bbi.2018.06.009 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2018 Nov;74:79-85. doi: 10.1016/j.bbi.2018.06.009. Epub 2018 
      Jun 12.