PMID- 29907502
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20190109
IS  - 1879-8519 (Electronic)
IS  - 1879-8500 (Linking)
VI  - 8
IP  - 6
DP  - 2018 Nov-Dec
TI  - Functional liver image guided hepatic therapy (FLIGHT) with hepatobiliary 
      iminodiacetic acid (HIDA) scans.
PG  - 429-436
LID - S1879-8500(18)30144-9 [pii]
LID - 10.1016/j.prro.2018.04.014 [doi]
AB  - PURPOSE: Hepatobiliary iminodiacetic acid (HIDA) scans provide global and 
      regional assessments of liver function that can serve as a road map for 
      functional avoidance in stereotactic body radiation therapy (SBRT) planning. 
      Functional liver image guided hepatic therapy (FLIGHT), an innovative planning 
      technique, is described and compared with standard planning using functional 
      dose-volume histograms. Thresholds predicting for decompensation during follow up 
      are evaluated. METHODS AND MATERIALS: We studied 17 patients who underwent HIDA 
      scans before SBRT. All SBRT cases were replanned using FLIGHT. The following 
      dosimetric endpoints were compared for FLIGHT versus standard SBRT planning: 
      functional residual capacity <15 Gy (FRC(15)HIDA), mean liver dose (MLD), 
      equivalent uniform dose (EUD), and functional EUD (FEUD). Receiver operating 
      characteristics curves were used to evaluate whether baseline HIDA values, 
      standard cirrhosis scoring, and/or dosimetric data predicted clinical 
      decompensation. RESULTS: Compared with standard planning, FLIGHT significantly 
      improved FRC(15)HIDA (mean improvement: 5.3%) as well as MLD, EUD, and FEUD (P < 
      .05). Considerable interindividual variations in the extent of benefit were 
      noted. Decompensation during follow-up was associated with baseline global HIDA 
      <2.915%/min/m(2), FRC(15)HIDA <2.11%/min/m(2), and MELD >/=11 (P < .05). 
      CONCLUSIONS: FLIGHT with HIDA-based parameters may complement blood 
      chemistry-based assessments of liver function and facilitate individualized, 
      adaptive liver SBRT planning.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Long, David E
AU  - Long DE
AD  - Indiana University, Department of Radiation Oncology, Indianapolis, Indiana.
FAU - Tann, Mark
AU  - Tann M
AD  - Indiana University, Department of Nuclear Medicine, Indianapolis, Indiana.
FAU - Huang, Ke Colin
AU  - Huang KC
AD  - Indiana University, Department of Radiation Oncology, Indianapolis, Indiana.
FAU - Bartlett, Gregory
AU  - Bartlett G
AD  - Indiana University, Department of Radiation Oncology, Indianapolis, Indiana.
FAU - Galle, James O
AU  - Galle JO
AD  - Indiana University, Department of Radiation Oncology, Indianapolis, Indiana.
FAU - Furukawa, Yukie
AU  - Furukawa Y
AD  - Columbus Regional Health, Department of Radiation Oncology, Columbus, Indiana.
FAU - Maluccio, Mary
AU  - Maluccio M
AD  - Indiana University, Department of Surgery, Indianapolis, Indiana.
FAU - Cox, John A
AU  - Cox JA
AD  - Columbus Regional Health, Department of Radiation Oncology, Columbus, Indiana.
FAU - Kong, Feng-Ming Spring
AU  - Kong FS
AD  - Indiana University, Department of Radiation Oncology, Indianapolis, Indiana.
FAU - Ellsworth, Susannah G
AU  - Ellsworth SG
AD  - Indiana University, Department of Radiation Oncology, Indianapolis, Indiana. 
      Electronic address: sgellswo@iu.edu.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180501
PL  - United States
TA  - Pract Radiat Oncol
JT  - Practical radiation oncology
JID - 101558279
RN  - 0 (Imino Acids)
RN  - XQM2L81M8Z (iminodiacetic acid)
SB  - IM
MH  - Biliary Tract/*diagnostic imaging
MH  - Carcinoma, Hepatocellular/diagnostic imaging/pathology/*surgery
MH  - Humans
MH  - Imino Acids/*chemistry
MH  - Liver Neoplasms/diagnostic imaging/pathology/*surgery
MH  - Prognosis
MH  - ROC Curve
MH  - *Radiosurgery
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/methods
MH  - Retrospective Studies
MH  - Surgery, Computer-Assisted/*methods
EDAT- 2018/06/17 06:00
MHDA- 2019/01/10 06:00
CRDT- 2018/06/17 06:00
PHST- 2018/01/30 00:00 [received]
PHST- 2018/04/05 00:00 [revised]
PHST- 2018/04/25 00:00 [accepted]
PHST- 2018/06/17 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2018/06/17 06:00 [entrez]
AID - S1879-8500(18)30144-9 [pii]
AID - 10.1016/j.prro.2018.04.014 [doi]
PST - ppublish
SO  - Pract Radiat Oncol. 2018 Nov-Dec;8(6):429-436. doi: 10.1016/j.prro.2018.04.014. 
      Epub 2018 May 1.