PMID- 29907668
OWN - NLM
STAT- MEDLINE
DCOM- 20191111
LR  - 20191111
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 45
IP  - 8
DP  - 2018 Aug
TI  - Longterm Outcomes of 188 Japanese Patients with Eosinophilic Granulomatosis with 
      Polyangiitis.
PG  - 1159-1166
LID - 10.3899/jrheum.171352 [doi]
AB  - OBJECTIVE: Patients with eosinophilic granulomatosis with polyangiitis (EGPA) 
      frequently experience relapses, which lead to cumulative organ damage. In this 
      retrospective observational study, we aimed to reveal the risk factors for 
      relapse in EGPA. METHODS: A total of 188 Japanese patients with EGPA diagnosed 
      between 1996 and 2015 were identified from medical records in 10 hospitals. The 
      diagnosis was based on the American College of Rheumatology 1990 criteria or 
      Lanham's criteria. Baseline characteristics, treatments, asthma exacerbation, and 
      relapses were evaluated by retrospective chart review. RESULTS: The median 
      followup period was 56 months. The median age at disease onset was 59.7 years. At 
      the disease onset, 95.2% of the patients had a history of bronchial asthma and 
      44.7% were positive for antineutrophil cytoplasmic antibodies. The cumulative 
      survival and relapse-free survival rates at 5 years were 89.6% and 64.0%, 
      respectively. Multivariate analysis with 2 models, proportional hazards, and 
      competing risk models, was performed to identify the factors associated with 
      relapse. The proportional hazards model identified azathioprine (AZA) maintenance 
      therapy and high eosinophil counts at onset as independent factors with lower 
      relapse risks, and high immunoglobulin E (IgE) levels at onset as a risk factor 
      for relapse. The competing risk model identified no statistically significant 
      factors. CONCLUSION: Although potential benefit of AZA maintenance therapy in 
      preventing relapse of EGPA was suggested by the proportional hazards model, there 
      was a discrepancy in the results between the models. Eosinophil counts and IgE 
      levels at onset were also identified as candidates of factors associated with 
      relapse in EGPA.
FAU - Saku, Aiko
AU  - Saku A
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Furuta, Shunsuke
AU  - Furuta S
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan. 
      shfuruta@chiba-u.jp.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital. 
      shfuruta@chiba-u.jp.
FAU - Hiraguri, Masaki
AU  - Hiraguri M
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Ikeda, Kei
AU  - Ikeda K
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Kobayashi, Yoshihisa
AU  - Kobayashi Y
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Kagami, Shin-Ichiro
AU  - Kagami SI
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Kurasawa, Kazuhiro
AU  - Kurasawa K
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Matsumura, Ryutaro
AU  - Matsumura R
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Nakagomi, Daiki
AU  - Nakagomi D
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Sugiyama, Takao
AU  - Sugiyama T
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Umibe, Takeshi
AU  - Umibe T
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Watanabe, Norihiko
AU  - Watanabe N
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
FAU - Nakajima, Hiroshi
AU  - Nakajima H
AD  - From the Department of Allergy and Clinical Immunology, Chiba University 
      Hospital; Department of Internal Medicine, Narita Red Cross Hospital; Department 
      of Internal Medicine, Chiba Aoba Municipal Hospital; Department of Allergy and 
      Clinical Immunology, Asahi General Hospital, Chiba; Department of Rheumatology, 
      Dokkyo Medical University, Tochigi; Department of Rheumatology, Allergy and 
      Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba; 
      Third Department of Internal Medicine, University of Yamanashi, Yamanashi; 
      Department of Rheumatology, National Hospital Organization Shimoshizu Hospital; 
      Department of Internal Medicine, Matsudo City Hospital; Centre for Rheumatic 
      Diseases, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
AD  - A. Saku, MD, Chiba University Hospital; S. Furuta, MD, PhD, Chiba University 
      Hospital; M. Hiraguri, MD, PhD, Narita Red Cross Hospital; K. Ikeda, MD, PhD, 
      Chiba University Hospital; Y. Kobayashi, MD, PhD, Chiba Aoba Municipal Hospital; 
      S.I. Kagami, MD, PhD, Asahi General Hospital; K. Kurasawa, MD, PhD, Dokkyo 
      Medical University; R. Matsumura, MD, PhD, Chiba-East Hospital; D. Nakagomi, MD, 
      PhD, University of Yamanashi; T. Sugiyama, MD, PhD, Shimoshizu Hospital; T. 
      Umibe, MD, PhD, Matsudo City Hospital; N. Watanabe, MD, PhD, Chibaken Saiseikai 
      Narashino Hospital; H. Nakajima, MD, PhD, Chiba University Hospital.
LA  - eng
PT  - Journal Article
DEP - 20180615
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Immunosuppressive Agents)
RN  - MRK240IY2L (Azathioprine)
SB  - IM
MH  - Aged
MH  - Azathioprine/*therapeutic use
MH  - Churg-Strauss Syndrome/diagnosis/*drug therapy
MH  - Eosinophils
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES-ASSOCIATED VASCULITIS
OT  - EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS
OT  - JAPAN
OT  - OUTCOME
OT  - RELAPSE
EDAT- 2018/06/17 06:00
MHDA- 2019/11/12 06:00
CRDT- 2018/06/17 06:00
PHST- 2018/03/07 00:00 [accepted]
PHST- 2018/06/17 06:00 [pubmed]
PHST- 2019/11/12 06:00 [medline]
PHST- 2018/06/17 06:00 [entrez]
AID - jrheum.171352 [pii]
AID - 10.3899/jrheum.171352 [doi]
PST - ppublish
SO  - J Rheumatol. 2018 Aug;45(8):1159-1166. doi: 10.3899/jrheum.171352. Epub 2018 Jun 
      15.