PMID- 2990769
OWN - NLM
STAT- MEDLINE
DCOM- 19850926
LR  - 20231213
IS  - 0730-0077 (Print)
IS  - 0730-0077 (Linking)
VI  - 7
IP  - 5-6
DP  - 1985
TI  - Plasma Na+-K+ ATPase inhibitory activity in normal and hypertensive subjects: 
      relationship to intracellular electrolytes and blood pressure.
PG  - 735-53
AB  - The ability of plasma extracts to inhibit Na+-K+ ATPase in vitro (P.I.A.) was 
      tested in 20 normotensives, 10 without (F-) and 10 with (F+) familial 
      hypertension, in 20 borderlines (BL) and in 21 essential hypertensives (EH). In 
      these subjects we also measured intralymphocytic sodium (ILSC) and potassium 
      (ILKC) content, P.R.A. urinary aldosterone and Na+(Na+u), and blood pressure. 
      P.I.A. of EH, BL and F+ subjects was significantly higher than that of F-. 60% of 
      EH and BL and 40% of F+ had P.I.A. values greater than the highest found in F-. 
      P.I.A. was significantly related to mean blood pressure (r = 0.63), to ILSC (r = 
      0.56), to ILKC (r = -0.56), to ILSC/ILKC ratio (r = 0.71) and to Na+u (r = 0.39) 
      but not to P.R.A. or aldosterone. These data demonstrate that plasma extracts 
      from young subjects prone to hypertension may inhibit sodium pump and that this 
      inhibitor may affect blood pressure by altering the Na+/K+ intracellular ratio.
FAU - Boschi, S
AU  - Boschi S
FAU - Borghi, C
AU  - Borghi C
FAU - Costa, F V
AU  - Costa FV
FAU - Ambrosioni, E
AU  - Ambrosioni E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Exp Hypertens A
JT  - Clinical and experimental hypertension. Part A, Theory and practice
JID - 8207790
RN  - 0 (Blood Proteins)
RN  - 0 (Electrolytes)
RN  - 0 (Proteins)
RN  - 4964P6T9RB (Aldosterone)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Adult
MH  - Aldosterone/urine
MH  - Animals
MH  - *Blood Pressure
MH  - *Blood Proteins
MH  - Electrolytes/*blood
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Hypertension/*blood
MH  - Lymphocytes/analysis
MH  - Male
MH  - Potassium/blood
MH  - *Proteins
MH  - Sodium/blood
MH  - Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors
MH  - Swine
MH  - ATPase Inhibitory Protein
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.3109/10641968509077224 [doi]
PST - ppublish
SO  - Clin Exp Hypertens A. 1985;7(5-6):735-53. doi: 10.3109/10641968509077224.